2015-至今：中国科学院生物与化学交叉研究中心，研究员、课题组长

Interdisciplinary Research Center on Biology and Chemistry,Chinese Academy of Sciences,Shanghai

2013-2015：耶鲁大学医学院，副研究科学家

Associate Research Scientist,Yale University School of Medicine,New Haven,Connecticut

2009-2012：美国国立卫生研究院，博士后

Postdoctoral Fellow,National Institutes of Health (NIH),Bethesda,Maryland

2004-2009：中国科学院生物物理研究所，生物化学博士

Ph.D.,Institute of Biophysics,Chinese Academy of Sciences,Beijing

2000-2004: 山东大学生物科学系，理学学士

B.Sc.,College of Life Sciences,Shandong University,Jinan

Representative publications (*corresponding author)

1.    Ji J,Cui MK,Zou R,Wu MZ,Ge MX,Li J,& Zhang ZR*. (2024) An ATP13A1-assisted topogenesis pathway for folding multi-spanning membrane proteins. Molecular Cell,84,1917-1931

²  Highlighted with commentary by Ramanujan Hegde: Getting Membrane Proteins into Shape. Molecular Cell,84,1821-1823

2.    Hu X,Zou R,Zhang Z,Ji J,Li J,Huo XY,Liu D,Ge MX,Cui MK,Wu MZ,Li ZP,Wang Q,Zhang X & Zhang ZR*. (2023) UBE4A catalyzes NRF1 ubiquitination and facilitates DDI2-mediated NRF1 cleavage. Biochim Biophys Acta Gene Regul Mech. 1866: 194937

3.    Wang L,Li J,Wang Q,Ge MX,Ji J,Liu D,Wang Z,Cao Y,Zhang Y & Zhang ZR*. (2022) TMUB1 is an endoplasmic reticulum-resident escortase that promotes p97-mediated extraction of membrane proteins for degradation. Molecular Cell 82,3453-3467

4.    Hu X,Wang L,Wang Y,Ji J,Li J,Wang Z,Li C,Zhang Y & Zhang ZR*. (2020) RNF126-mediated reubiquitination is required for proteasomal degradation of p97-extracted membrane proteins. Molecular Cell 79,320-331

²  Highlighted with commentary by Claudia Schmidt and Alexander Stein: Off and On Again: De- and Reubiquitination during Membrane Protein Degradation. Molecular Cell,79,203-204

5.    Shi J,Hu X,Guo Y,Wang L,Ji J,Li J & Zhang ZR*. (2019) A technique for delineating the unfolding requirements for substrate entry into retrotranslocons during endoplasmic reticulum-associated degradation. J Biol Chem. 294,20084-20096. Recommended in Faculty of 1000

6.    Zhang ZR*,Bonifacino JS & Hegde RS*. (2013) Deubiquitinases sharpen substrate discrimination during membrane protein degradation from the ER. Cell 154,609-622,

²  Highlighted with commentary by Jeffrey Brodsky: Just a trim,please: refining ER degradation through deubiquitination. Cell,154,479-481

Other publications (#first author):

1.    Zhang M,Wang Z,Zhao Q,Yang Q,Bai J,Yang C, Zhang ZR,Liu Y*. (2024) USP20 deubiquitinates and stabilizes the reticulophagy receptor RETREG1/FAM134B to drive reticulophagy. Autophagy. Online ahead of print.

2.    Hou X,Zhang X,Zou H,Guan M,Fu C,Wang W, Zhang ZR,Geng Y* & Chen Y*. (2023) Differential and substrate-specific inhibition of γ-secretase by the C-terminal region of ApoE2,ApoE3,and ApoE4. Neuron. 111,1898-1913

3.    Liang W,Qi W,Geng Y,Wang L,Zhao J,Zhu K,Wu G, Zhang ZR,Pan H,Qian L & Yuan J*. (2021) Necroptosis activates UPR sensors without disrupting their binding with GRP78. Proc Natl Acad Sci USA. 118 (39):e2110476118.

4.    Coelho JPL,Stahl M,Bloemeke N,Meighen-Berger K,Alvira CP, Zhang ZR,Sieber SA & Feige MJ*. (2019) A network of chaperones prevents and detects failures in membrane protein lipid bilayer integration. Nat Commun. 10,672.

5.    Plumb R#, Zhang ZR#,Appathurai S & Mariappan M*. (2015) A functional link between the co-translational protein translocation pathway and the UPR. eLife 4,e07426 (#co-first author)

6.    Park SY,Waheed AA, Zhang ZR,Freed EO & Bonifacino JS*. (2014) HIV-1 Vpu accessory protein induces caspase-mediated cleavage of IRF3 transcription factor. J. Biol. Chem. 289,35102-35110

7.    Moran C,Kinsella GK, Zhang ZR,Perrett S & Jones GW*. (2013) Mutational Analysis of Sse1 (Hsp110) Suggests an Integral Role for this Chaperone in Yeast Prion Propagation In Vivo. G3: Genes,Genomes,Genetics 3,1409-1418

8.    Emerman AB, Zhang ZR, Chakrabarti O & Hegde RS*. (2010). Compartment-restricted biotinylation reveals novel features of prion protein metabolism in vivo. Mol. Biol. Cell 21,4325-4337

9.    Zhang C,Jackson A, Zhang ZR,Han Y,Yu S,He RQ & Perrett S*. (2010). Amyloid-Like aggregates of the yeast prion protein Ure2 enter vertebrate cells by specific endocytotic pathways and induce apoptosis. PLoS ONE 5,e12529

10.  Zhang ZR# & Perrett S*. (2009). Novel glutaredoxin activity of the yeast prion protein Ure2 reveals a native-like dimer within fibrils. J. Biol. Chem. 284,14058-14067

11.  Wang XY, Zhang ZR & Perrett S*. (2009). Characterization of the activity and folding of the glutathione transferase from Escherichia coli and the roles of residues Cys10 and His106. Biochem. J. 417,55-64

12.  Zhang ZR#,Bai M,Wang XY,Zhou JM & Perrett S*. (2008)."Restoration"of glutathione transferase activity by single-site mutation of the yeast prion protein Ure2. J. Mol. Biol. 384,641-651

13.  Lian HY,Zhang H, Zhang ZR,Loovers HM,Jones GW,Rowling PJ,Itzhaki LS,Zhou JM & Perrett S*. (2007). Hsp40 interacts directly with the native state of the yeast prion protein Ure2 and inhibits formation of amyloid-like fibrils. J. Biol. Chem. 282,11931-11940