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张耀阳

张耀阳

学历:博士研究生
职称:研究员
邮箱:zyy@sioc.ac.cn
电话:021-68582550
地址:上海市浦东新区秋月路26号6号楼205

简介
2000-2006 北京理工大学 学士和硕士
2006-2010 德国慕尼黑-路德维希-马克西米利安大学 博士
2006-2010 德国马克斯普朗克精神病研究所 博士生
2011-2013.9 美国斯克里普斯研究所 研究助理
2013.9-至今 中国科学院生物与化学交叉研究中心 研究员、课题组长
研究方向
质谱和蛋白质组实验室利用生物质谱技术来研究蛋白质在生物体系中的多种特性。其研究方向主要包括:
1.质谱蛋白质组学新技术和新方法的研究
2.神经退行性疾病和衰老过程的相关蛋白质组学研究
3.质谱蛋白质组学技术在生物学问题中的广泛应用
代表论文
(1) Yang, L.; Ma, Z.; Wang, H.; Niu, K.; Cao, Y.; Sun, L.; Geng, Y.; Yang, B.; Gao, F.;Chen, Z.; Wu, Z.; Li, Q.; Shen, Y.; Zhang, X.; Jiang, H.; Chen, Y.; Liu, R.; Liu, N.*; Zhang, Y.* Ubiquitylomestudy identifies increased histone 2A ubiquitylation as an evolutionarily conserved aging biomarker. Nat Commun 2019, 10, 2191.

(2) Qiang, J.; Ma, Z.; Xie, X.; Shi, L.; Geng, Y.; Hu, J.; Liu, R.; Liu, N.; Zhang, Y.* Multi-omic Analyses Reveal Minimal Impact of the CRISPR-Cas9 Nuclease on Cultured Human Cells. J Proteome Res 2019, 18, 1054-1063.

(3) Ma, Z.; Wang, H.; Cai, Y.; Wang, H.; Niu, K.; Wu, X.; Ma, H.; Yang, Y.; Tong, W.; Liu, F.; Liu, Z.; Zhang, Y.; Liu, R.; Zhu, Z. J.*; Liu, N.* Epigenetic drift of H3K27me3 in aging links glycolysis to healthy longevity in Drosophila. Elife 2018, 7.

(4) Guo, L.; Yang, W.; Huang, Q.; Qiang, J.; Hart, J. R.; Wang, W.; Hu, J.; Zhu, Z. J.; Liu, N.; Zhang, Y.* Selenocysteine-Specific Mass Spectrometry Reveals Tissue-Distinct Selenoproteomes and Candidate Selenoproteins. Cell Chem Biol 2018, 25, 1380-1388.

(5) Yang, X.; Wang, Z.; Guo, L.; Zhu, Z. J.; Zhang, Y.* Proteome-Wide Analysis of N-Glycosylation Stoichiometry Using SWATH Technology. J Proteome Res 2017, 16,3830-3840.

(6) Mu, R.; Tat, J.; Zamudio, R.; Zhang, Y.; Yates, J. R., 3rd; Kumagai, A.; Dunphy, W. G.; Reed, S. I.* CKS ProteinsPromote Checkpoint Recovery by Stimulating Phosphorylation of Treslin. Mol Cell Biol 2017, 37.

(7) Jin, H. Y.; Oda, H.; Chen, P.; Yang, C.; Zhou, X.; Kang, S. G.; Valentine, E.; Kefauver, J. M.; Liao, L.; Zhang, Y.; Gonzalez-Martin, A.; Shepherd, J.; Morgan, G. J.; Mondala, T. S.; Head, S. R.;Kim, P. H.; Xiao, N.; Fu, G.; Liu, W. H.; Han, J.; Williamson, J. R.; Xiao, C.* Differential Sensitivity of Target Genes to Translational Repression bymiR-17~92. PLoS Genet 2017, 13,e1006623.

(8) Wang, H.; Ma, Z.; Niu, K.; Xiao, Y.; Wu, X.; Pan, C.; Zhao, Y.; Wang, K.; Zhang, Y.; Liu, N.* Antagonistic roles of Nibbler and Hen1 in modulating piRNA 3' ends in Drosophila. Development 2016, 143, 530-539.

(9) Pedros, C.; Zhang, Y.; Hu, J. K.; Choi, Y.S.; Canonigo-Balancio, A. J.; Yates, J. R., 3rd; Altman, A.; Crotty, S.; Kong,K. F.* A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1. Nat Immunol 2016, 17, 825-833.

(10) Zhang, Y.; Xu, T.; Shan, B.; Hart, J.; Aslanian, A.; Han, X.; Zong, N.; Li, H.; Choi, H.; Wang, D.; Acharya, L.; Du,L.; Vogt, P. K.; Ping, P.; Yates, J. R., 3rd.* ProteinInferencer: Confidentprotein identification and multiple experiment comparison for large scale proteomics projects. J Proteomics 2015, 129, 25-32.

(11) Xia, H. G.; Najafov, A.; Geng, J.; Galan-Acosta, L.; Han, X.; Guo, Y.; Shan, B.; Zhang, Y.; Norberg, E.; Zhang, T.; Pan,L.; Liu, J.; Coloff, J. L.; Ofengeim, D.; Zhu, H.; Wu, K.; Cai, Y.; Yates, J.R., 3rd; Zhu, Z. J.; Yuan, J. *; Vakifahmetoglu-Norberg, H. Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death. J Cell Biol 2015, 210, 705-716.

(12) Tang, B.; Wang, T.; Wan, H.; Han, L.; Qin, X.; Zhang, Y.; Wang, J.; Yu, C.; Berton, F.; Francesconi, W.; Yates, J. R., 3rd; Vanderklish, P. W.; Liao, L.* Fmr1 deficiency promotes age-dependent alterations in the cortical synaptic proteome. Proc Natl Acad Sci U S A 2015, 112, E4697-4706.

(13) Ofengeim, D.; Ito, Y.; Najafov, A.; Zhang, Y.; Shan, B.; DeWitt, J. P.; Ye, J.; Zhang, X.; Chang, A.; Vakifahmetoglu-Norberg, H.; Geng, J.; Py, B.; Zhou, W.; Amin, P.; Berlink Lima, J.; Qi, C.; Yu, Q.; Trapp, B.; Yuan, J.* Activation of necroptosis in multiple sclerosis. Cell Rep 2015, 10, 1836-1849.

(14) Huang, Q.; Yang, L.; Luo, J.; Guo, L.; Wang, Z.; Yang, X.; Jin, W.; Fang, Y.; Ye, J.;Shan, B.; Zhang, Y.* SWATH enables precise label-free quantification on proteome scale. Proteomics 2015, 15, 1215-1223.

(15) Hassler, J. R.; Scheuner, D. L.; Wang, S.; Han, J.; Kodali, V. K.; Li, P.; Nguyen, J.; George, J. S.; Davis, C.; Wu, S. P.; Bai, Y.; Sartor, M.; Cavalcoli, J.; Malhi, H.; Baudouin, G.; Zhang, Y.; Yates, J. R., 3rd; Itkin-Ansari, P.; Volkmann, N.; Kaufman, R. J.* The IRE1alpha/XBP1s Pathway Is Essential for the Glucose Response and Protection of beta Cells. PLoS Biol 2015, 13, e1002277.

(16) Hart, J. R.; Zhang, Y.; Liao, L.; Ueno, L.; Du, L.; Jonkers, M.; Yates, J. R., 3rd; Vogt, P. K.* The butterfly effect in cancer: a single base mutation can remodel the cell. Proc Natl Acad Sci U S A 2015, 112, 1131-1136.

(17) Zhang, Y.; Shan, B.; Boyle, M.; Liu, J.; Liao, L.; Xu, T.; Yates, J. R., 3rd.* Brain Proteome Changes Induced by Olfactory Learning in Drosophila. J Proteome Res 2014, 13, 3763-3770.

(18) Shan, B.; Xu, C.; Zhang, Y.; Xu, T.; Gottesfeld, J. M.; Yates, J. R., 3rd.* Quantitative proteomic analysis identifies targets and pathways of a 2-aminobenzamide HDAC inhibitor in Friedreich's ataxia patient iPSC-derived neural stem cells. J Proteome Res 2014, 13, 4558-4566.

(19) Kong, K. F.; Fu, G.; Zhang, Y.; Yokosuka, T.; Casas, J.; Canonigo-Balancio, A. J.; Becart, S.; Kim, G.; Yates, J. R., 3rd; Kronenberg, M.; Saito, T.; Gascoigne, N. R.; Altman, A.* Protein kinase C-eta controls CTLA-4-mediated regulatory T cell function. Nat Immunol 2014, 15, 465-472.

(20) Zhang, Y.; Fonslow, B. R.; Shan, B.;Baek, M. C.; Yates, J. R., 3rd.* Protein analysis by shotgun/bottom-up proteomics. Chem Rev 2013, 113, 2343-2394.

(21) Webhofer, C.; Zhang, Y.; Brusis, J.; Reckow, S.; Landgraf, R.; Maccarrone, G.; Turck, C. W.; Filiou, M. D.* (1)(5)N metabolic labeling: evidence for a stable isotope effect on plasma protein levels and peptide chromato graphic retention times. J Proteomics 2013, 88, 27-33.

(22) Ryan, S. D.; Dolatabadi, N.; Chan, S. F.; Zhang, X.; Akhtar, M. W.; Parker, J.; Soldner, F.; Sunico, C. R.; Nagar, S.; Talantova, M.; Lee, B.; Lopez, K.; Nutter, A.; Shan, B.; Molokanova, E.; Zhang, Y.; Han, X.; Nakamura, T.; Masliah, E.; Yates, J. R., 3rd; Nakanishi, N.; Andreyev, A. Y.; Okamoto, S.; Jaenisch, R.*; Ambasudhan, R.*; Lipton, S. A.* Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1 alpha transcription. Cell 2013, 155, 1351-1364.

(23) Filiou, M. D.; Webhofer, C.; Gormanns, P.; Zhang, Y.; Reckow, S.; Bisle, B.; Teplytska, L.; Frank, E.; Kessler, M. S.; Maccarrone, G.; Landgraf, R.; Turck, C. W.* The (15)N isotope effect as a means for correlating phenotypic alterations and affected pathways in a trait anxiety mouse model. Proteomics 2012, 12,2421-2427.

(24) Zhang, Y.; Reckow, S.; Webhofer, C.; Boehme, M.; Gormanns, P.; Egge-Jacobsen, W. M.; Turck, C. W.* Proteome scale turnover analysis in live animals using stable isotope metabolic labeling. Anal Chem 2011, 83, 1665-1672.

(25) Zhang, Y.; Filiou, M. D.; Reckow, S.; Gormanns, P.; Maccarrone, G.; Kessler, M. S.; Frank, E.; Hambsch, B.; Holsboer, F.; Landgraf, R.; Turck, C. W.* Proteomic and metabolomic profiling of a trait anxiety mouse model implicate affected pathways. Mol Cell Proteomics 2011, 10, M111008110.

(26) Filiou, M. D.; Zhang, Y.; Teplytska, L.; Reckow, S.; Gormanns, P.; Maccarrone, G.; Frank, E.; Kessler, M. S.; Hambsch, B.; Nussbaumer, M.; Bunck, M.; Ludwig, T.; Yassouridis, A.; Holsboer, F.; Landgraf, R.; Turck, C. W.* Proteomics and metabolomics analysis of a trait anxiety mouse model reveals divergent mitochondrial pathways. Biol Psychiatry 2011, 70, 1074-1082.

(27) Zhang, Y.; Webhofer, C.; Reckow, S.; Filiou, M. D.; Maccarrone, G.; Turck, C. W.* A MS data search method forimproved 15N-labeled protein identification. Proteomics 2009, 9, 4265-4270.

(28) Haegler, K.; Mueller, N. S.; Maccarrone, G.; Hunyadi-Gulyas, E.; Webhofer, C.; Filiou, M. D.; Zhang, Y.; Turck, C. W.* QuantiSpec--Quantitative mass spectrometry data analysis of (15)N-metabolically labeled proteins. J Proteomics 2009,71, 601-608.

(29) Frank, E.; Kessler, M. S.; Filiou, M. D.; Zhang, Y.; Maccarrone, G.; Reckow, S.; Bunck, M.; Heumann, H.; Turck, C. W.; Landgraf, R.; Hambsch, B.* Stable isotope metabolic labeling with a novel N-enriched bacteria diet for improved proteomic analyses of mouse models forpsychopathologies. PLoS One 2009, 4,e7821.

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