中文 | EN
学历:博士研究生
职称:研究员
邮箱:zrzhang@sioc.ac.cn
电话:021-68582263
地址:上海市浦东新区海科路100号
2015-至今:中国科学院生物与化学交叉研究中心,研究员、课题组长
Interdisciplinary Research Center on Biology and Chemistry, Chinese Academy of Sciences, Shanghai
2013-2015:耶鲁大学医学院,副研究科学家
Associate Research Scientist, Yale University School of Medicine, New Haven, Connecticut
2009-2012:美国国立卫生研究院,博士后
Postdoctoral Fellow, National Institutes of Health (NIH), Bethesda, Maryland
2004-2009:中国科学院生物物理研究所,生物化学博士
Ph.D., Institute of Biophysics, Chinese Academy of Sciences, Beijing
2000-2004: 山东大学生物科学系,理学学士
B.Sc., College of Life Sciences, Shandong University, Jinan
Selected publications
1. Wang L, Li J, Wang Q, Ge MX, Ji J, Liu D, Wang Z, Cao Y, Zhang Y, and Zhang ZR*. (2022) TMUB1 is an endoplasmic reticulum-resident escortase that promotes p97-mediated extraction of membrane proteins for degradation. Mol Cell. doi: 10.1016/j.molcel.2022.07.006. Online ahead of print. PMID: 35961308
2. Hu X, Wang L, Wang Y, Ji J, Li J, Wang Z, Li C, Zhang Y, and Zhang ZR*. (2020) RNF126-Mediated Reubiquitination Is Required for Proteasomal Degradation of p97-Extracted Membrane Proteins. Mol Cell. 79, 320-331
3. Shi J, Hu X, Guo Y, Wang L, Ji J, Li J, and Zhang ZR*. (2019) A technique for delineating the unfolding requirements for substrate entry into retrotranslocons during endoplasmic reticulum-associated degradation. J Biol Chem. 294, 20084-20096.
4. Coelho JPL, Stahl M, Bloemeke N, Meighen-Berger K, Alvira CP, Zhang ZR, Sieber SA, and Feige MJ. (2019) A network of chaperones prevents and detects failures in membrane protein lipid bilayer integration. Nat Commun. 10, 672.
5. Plumb R#, Zhang ZR#, Appathurai S, and Mariappan M. (2015) A functional link between the co-translational protein translocation pathway and the UPR. eLife 4: e07426
6. Park SY, Waheed AA, Zhang ZR, Freed EO, and Bonifacino JS. (2014) HIV-1 Vpu accessory protein induces caspase-mediated cleavage of IRF3 transcription factor. J Biol Chem. 289, 35102-35110
7. Zhang ZR*, Bonifacino JS, and Hegde RS*. (2013) Deubiquitinases Sharpen Substrate Discrimination during Membrane Protein Degradation from the ER. Cell 154, 609-622 (* Co-corresponding authors)
8. Moran C, Kinsella GK, Zhang ZR, Perrett S, and Jones GW. (2013) Mutational Analysis of Sse1 (Hsp110) Suggests an Integral Role for this Chaperone in Yeast Prion Propagation In Vivo. G3: Genes, Genomes, Genetics 3, 1409-1418
9. Emerman AB, Zhang ZR, Chakrabarti O, and Hegde RS. (2010). Compartment-restricted biotinylation reveals novel features of prion protein metabolism in vivo. Mol Biol Cell 21, 4325-4337
10. Zhang C, Jackson A, Zhang ZR, Han Y, Yu S, He RQ, and Perrett S. (2010). Amyloid-Like aggregates of the yeast prion protein Ure2 enter vertebrate cells by specific endocytotic pathways and induce apoptosis. PLoS One 5, e12529
11. Zhang ZR, and Perrett S. (2009). Novel glutaredoxin activity of the yeast prion protein Ure2 reveals a native-like dimer within fibrils. J Biol Chem. 284, 14058-14067
12. Wang XY, Zhang ZR, and Perrett S. (2009). Characterization of the activity and folding of the glutathione transferase from Escherichia coli and the roles of residues Cys10 and His106. Biochem J. 417(1):55-64
13. Zhang ZR, Bai M, Wang XY, Zhou JM and Perrett S. (2008). "Restoration" of glutathione transferase activity by single-site mutation of the yeast prion protein Ure2. J Mol Biol. 384, 641-651
14. Lian HY, Zhang H, Zhang ZR, Loovers HM, Jones GW, Rowling PJ, Itzhaki LS, Zhou JM and Perrett S. (2007). Hsp40 interacts directly with the native state of the yeast prion protein Ure2 and inhibits formation of amyloid-like fibrils. J Biol Chem. 282, 11931-11940
15. Liang W, Qi W, Geng Y, Wang L, Zhao J, Zhu K, Wu G, Zhang Z, Pan H, Qian L, Yuan J. (2021) Necroptosis activates UPR sensors without disrupting their binding with GRP78. Proc Natl Acad Sci USA. 118(39): e2110476118.