2009.9-2017.6    北京大学 基础医学八年制本博连读

2009.9-2014.6    北京大学 基础医学 医学学士学位

2011.9-2014.6    北京大学 汉语言文学 文学学士双学位

2014.9-2017.6    北京大学 医学生物化学与分子生物学 博士学位

2017.11-2021.6  哈佛大学 博士后

2021.8-至今        中国科学院生物与化学交叉中心 研究员，课题组长

李婉津课题组致力于研究调控多种疾病如脊髓侧索硬化症、阿兹海默症等神经退行性疾病及肿瘤耐药过程中炎症反应的表观遗传及基因转录调控机制，联合分子生物学、细胞生物学和生物信息学等手段对疾病中转录活动中的染色质重塑异常和组蛋白修饰变化进行鉴定和探索。

课题组具体研究方向为：

1.  细胞死亡、炎症的关键调控分子在细胞核内的表观遗传调控功能鉴定；

2.  调节关键蛋白细胞核质转运的小分子药物的发现和作用机理研究；

3.  人类疾病中染色质重塑复合物的基因突变所造成病理变化的分子机制；

4.  肿瘤耐药过程中的染色质重塑和长链非编码RNA调控机制。

代表论文

https://scholar.google.com/citations?hl=en&user=VpWN2-gAAAAJ&view_op=list_works&sortby=pubdate

(#equal contribution, *coresponding)

1.      Li, W.*, Shan, B., Zou, C., Wang, H., Zhang, M., Zhu, H., Naito, M. G., Xu, D., Manuel, V. J., Mifflin, L., Ravits, J. & Yuan, J*. Nuclear RIPK1 promotes chromatin remodeling for mediating inflammatory response. Cell Res, doi:10.1038/s41422-022-00673-3 (2022).

2.      Tao, P.#, Sun, J.#, Wu, Z.#, Wang, S.#, Wang, J.#, Li, W.#, Pan, H., Bai, R., Zhang, J., Wang, Y., Lee, P. Y., Ying, W., Zhou, Q., Hou, J., Wang, W., Sun, B., Yang, M., Liu, D., Fang, R., Han, H., Yang, Z., Huang, X., Li, H., Deuitch, N., Zhang, Y., Dissanayake, D., Haude, K., McWalter, K., Roadhouse, C., MacKenzie, J. J., Laxer, R. M., Aksentijevich, I., Yu, X.*, Wang, X.*, Yuan, J.* & Zhou, Q.* A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1. Nature 577, 109-114, doi:10.1038/s41586-019-1830-y (2020).

3.      Li, W., Zhang, Z., Liu, X., Cheng, X., Zhang, Y., Han, X., Zhang, Y., Liu, S., Yang, J., Xu, B., He, L., Sun, L., Liang, J. & Shang, Y*. The FOXN3-NEAT1-SIN3A repressor complex promotes progression of hormonally responsive breast cancer. J Clin Invest 127, 3421-3440, doi:10.1172/JCI94233 (2017).

4.      Naito, M. G., Xu, D., Amin, P., Lee, J., Wang, H., Li, W., Kelliher, M., Pasparakis, M. & Yuan, J*. Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke. Proc Natl Acad Sci U S A 117, 4959-4970, doi:10.1073/pnas.1916427117 (2020).

5.      Su, Z., Dziedzic, S. A., Hu, D., Barrett, V. J., Broekema, N., Li, W., Qian, L., Jia, N., Ofengeim, D., Najafov, A., Zhu, H., Knipe, D. M. & Yuan, J*. ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner. Cell Death Differ 26, 1077-1088, doi:10.1038/s41418-018-0215-3 (2019).

6.      Xu, D., Jin, T., Zhu, H., Chen, H., Ofengeim, D., Zou, C., Mifflin, L., Pan, L., Amin, P., Li, W., Shan, B., Naito, M. G., Meng, H., Li, Y., Pan, H., Aron, L., Adiconis, X., Levin, J. Z., Yankner, B. A. & Yuan, J*. TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging. Cell 174, 1477-1491 e1419, doi:10.1016/j.cell.2018.07.041 (2018).

7.      He, L., Liu, X., Yang, J., Li, W., Liu, S., Liu, X., Yang, Z., Ren, J., Wang, Y., Shan, L., Guan, C., Pei, F., Lei, L., Zhang, Y., Yi, X., Yang, X., Liang, J., Liu, R., Sun, L. * & Shang, Y*. Imbalance of the reciprocally inhibitory loop between the ubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis. Cell Res 28, 934-951, doi:10.1038/s41422-018-0079-6 (2018).

8.      Xie, G., Liu, X., Zhang, Y., Li, W., Liu, S., Chen, Z., Xu, B., Yang, J., He, L., Zhang, Z., Jin, T., Yi, X., Sun, L., Shang, Y. & Liang, J*. UTX promotes hormonally responsive breast carcinogenesis through feed-forward transcription regulation with estrogen receptor. Oncogene 36, 5497-5511, doi:10.1038/onc.2017.157 (2017).

9.      Liu, Y., Liu, S., Yuan, S., Yu, H., Zhang, Y., Yang, X., Xie, G., Chen, Z., Li, W., Xu, B., Sun, L., Shang, Y. & Liang, J*. Chromodomain protein CDYL is required for transmission/restoration of repressive histone marks. J Mol Cell Biol 9, 178-194, doi:10.1093/jmcb/mjx013 (2017).

10.   Liu, X., Si, W., Liu, X., He, L., Ren, J., Yang, Z., Yang, J., Li, W., Liu, S., Pei, F., Yang, X. & Sun, L.* JMJD6 promotes melanoma carcinogenesis through regulation of the alternative splicing of PAK1, a key MAPK signaling component. Mol Cancer 16, 175, doi:10.1186/s12943-017-0744-2 (2017).

11.   Liu, S., Yu, H., Liu, Y., Liu, X., Zhang, Y., Bu, C., Yuan, S., Chen, Z., Xie, G., Li, W., Xu, B., Yang, J., He, L., Jin, T., Xiong, Y., Sun, L., Liu, X., Han, C., Cheng, Z., Liang, J.* & Shang, Y.* Chromodomain Protein CDYL Acts as a Crotonyl-CoA Hydratase to Regulate Histone Crotonylation and Spermatogenesis. Mol Cell 67, 853-866 e855, doi:10.1016/j.molcel.2017.07.011 (2017).

12.   Li, L., Liu, X., He, L., Yang, J., Pei, F., Li, W., Liu, S., Chen, Z., Xie, G., Xu, B., Ting, X., Zhang, Z., Jin, T., Liu, X., Zhang, W., Yuan, S., Yang, Z., Wu, C., Zhang, Y., Yang, X., Yi, X., Liang, J., Shang, Y.* & Sun, L.* ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin. Nat Commun 8, 691, doi:10.1038/s41467-017-00702-5 (2017).

13.   Chen, Z., Gui, B., Zhang, Y., Xie, G., Li, W., Liu, S., Xu, B., Wu, C., He, L., Yang, J., Yi, X., Yang, X., Sun, L., Liang, J. & Shang, Y*. Identification of a 35S U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP) complex intermediate in spliceosome assembly. J Biol Chem 292, 18113-18128, doi:10.1074/jbc.M117.797357 (2017).

14.   Zhang, Y., Zhang, D., Li, Q., Liang, J., Sun, L., Yi, X., Chen, Z., Yan, R., Xie, G., Li, W., Liu, S., Xu, B., Li, L., Yang, J., He, L. & Shang, Y*. Nucleation of DNA repair factors by FOXA1 links DNA demethylation to transcriptional pioneering. Nat Genet 48, 1003-1013, doi:10.1038/ng.3635 (2016).

15.   Shan, L., Zhou, X., Liu, X., Wang, Y., Su, D., Hou, Y., Yu, N., Yang, C., Liu, B., Gao, J., Duan, Y., Yang, J., Li, W., Liang, J., Sun, L., Chen, K., Xuan, C., Shi, L., Wang, Y. & Shang, Y*. FOXK2 Elicits Massive Transcription Repression and Suppresses the Hypoxic Response and Breast Cancer Carcinogenesis. Cancer Cell 30, 708-722, doi:10.1016/j.ccell.2016.09.010 (2016).

16.   Li, L., Shi, L., Yang, S., Yan, R., Zhang, D., Yang, J., He, L., Li, W., Yi, X., Sun, L., Liang, J., Cheng, Z., Shi, L., Shang, Y.* & Yu, W*. SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability. Nat Commun 7, 12235, doi:10.1038/ncomms12235 (2016).

17.   Yan, R., He, L., Li, Z., Han, X., Liang, J., Si, W., Chen, Z., Li, L., Xie, G., Li, W., Wang, P., Lei, L., Zhang, H., Pei, F., Cao, D., Sun, L.* & Shang, Y*. SCF(JFK) is a bona fide E3 ligase for ING4 and a potent promoter of the angiogenesis and metastasis of breast cancer. Genes Dev 29, 672-685, doi:10.1101/gad.254292.114 (2015).

18.   Si, W., Huang, W., Zheng, Y., Yang, Y., Liu, X., Shan, L., Zhou, X., Wang, Y., Su, D., Gao, J., Yan, R., Han, X., Li, W., He, L., Shi, L., Xuan, C., Liang, J., Sun, L., Wang, Y.* & Shang, Y*. Dysfunction of the Reciprocal Feedback Loop between GATA3- and ZEB2-Nucleated Repression Programs Contributes to Breast Cancer Metastasis. Cancer Cell 27, 822-836, doi:10.1016/j.ccell.2015.04.011 (2015).

19.   Yang, X., Yang, J., Li, L., Sun, L., Yi, X., Han, X., Si, W., Yan, R., Chen, Z., Xie, G., Li, W., Shang, Y. & Liang, J*. PAAT, a novel ATPase and trans-regulator of mitochondrial ABC transporters, is critically involved in the maintenance of mitochondrial homeostasis. FASEB J 28, 4821-4834, doi:10.1096/fj.14-254045 (2014).

20.   Wang, F., He, L., Huangyang, P., Liang, J., Si, W., Yan, R., Han, X., Liu, S., Gui, B., Li, W., Miao, D., Jing, C., Liu, Z., Pei, F., Sun, L.* & Shang, Y*. JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation. PLoS Biol 12, e1001819, doi:10.1371/journal.pbio.1001819 (2014).

21.   Han, X., Gui, B., Xiong, C., Zhao, L., Liang, J., Sun, L., Yang, X., Yu, W., Si, W., Yan, R., Yi, X., Zhang, D., Li, W., Li, L., Yang, J., Wang, Y., Sun, Y. E., Zhang, D., Meng, A. & Shang, Y*. Destabilizing LSD1 by Jade-2 promotes neurogenesis: an antibraking system in neural development. Mol Cell 55, 482-494, doi:10.1016/j.molcel.2014.06.006 (2014).