周界文 (James J. Chou) 1994年毕业与美国密西根大学物理系，1999年美国哈佛大学生物物理学博士，1999-2002，在美国国立卫生研究院做博士后研究。2003-2011，在美国哈佛大学任助理教授，副教授，2012获得终身教授。2022年底全职回国加入中国科学院上海有机化学研究所和生物与化学交叉研究中心。周界文教授长期从事跨膜受体的信号传导机理和病毒与宿主膜融和机制方面的研究，为揭示这些蛋白在跨膜和近膜区域的盲点开发了一系列高分辨率核磁技术，并从中发现了重要的新生物功能与概念。

周界文教授长期从事跨膜受体的信号传导机理和病毒与宿主膜融和机制方面的研究，为揭示这些蛋白在跨膜和近膜区域的盲点开发了一系列生物化学和生物物理技术，并从中发现了重要的新生物功能与概念。课题组的研究目标是免疫和细胞因子受体在细胞表面的时空组织与其调控下游信号通路的机理。课题组的转化目标包括发现新型免疫治疗调控剂和多特异性药物提送体系。

2001       Life Science Award, GlaxoSmithKline Fellow

2003       The Smith Family New Investigator Award

2004       The Alexander and Margaret Stewart Trust Award

2004       PEW Scholar in the Biomedical Sciences

2006       Giovanni Armenise-Harvard Junior Faculty Award

2009       Genzyme Outstanding Achievement in Biomedical Science Award

2020       Q-FASTR Award for Advancing and Seeding Translational Research

Jason R. Schnell, James J. Chou*. Structure and Mechanism of the M2 Proton Channel of Influenza A Virus. Nature, 2008, 451 (7178), 591-5.

Chenqi Xu, Etienne Gagnon, Matthew E. Call, Jason R. Schnell, Charles D. Schwieters, Christopher V. Carman, James J. Chou*, Kai W. Wucherpfennig*. Regulation of T Cell Receptor Activation by Dynamic Membrane Binidng of the CD3e Cytoplasmic Tyrosine-Based Motif. Cell, 2008, 135 (4), 702-713.

Junfeng Wang, Rafal M. Pielak, Mark A. McClintock, James J. Chou*. Solution structure and functional analysis of the influenza B proton channel. Nat Struct & Mol Biol, 2009, 16 (12), 1267-71.

Matthew E. Call, Kai W. Wucherpfennig*, James J. Chou*. The structural basis for intramembrane assembly of an activating immunoreceptor complex. Nat Immunol, 2010, 11(11), 1023-9.

Rafal M. Pielak, James J. Chou*. Kinetic Analysis of the M2 Proton Conduction of the Influenza Virus. J Am Chem Soc, 2010, 32, 50, 17695–7.

Marcelo J. Berardi, William M. Shih, Stephen C. Harrison, James J. Chou*. Structure of the mitochondrial uncoupling protein 2 determined by NMR molecular fragment searching. Nature, 2011, 476 (7358), 109-13.

Bo OuYang, Shiqi Xie, Marcelo J. Berardi, Xinhao Zhao, Jyoti Dev, Wenjing Yu, Bing Sun*, James J. Chou*. Unusual architecture of the p7 channel from hepatitis C virus. Nature, 2013, 498 (7455), 521-5.

Marcelo J. Berardi, James J. Chou*. Fatty Acid Flippase Activity of UCP2 Is Essential for Its Proton Transport in Mitochondria. Cell Metabolism, 2014, 20 (3):541-52.

Sven Brüschweiler, Qin Yang, Changqing Run, James J. Chou*. Substrate Modulated Dynamics of the ADP/ATP Transporter Revealed by NMR Relaxation Dispersion. Nat Struct & Mol Biol, 2015, 22 (8), 636-41.

Jessica A. Williamson, Seung-Hyun Cho, Jiqing Ye, Jean-Francois Collet, Jonathan R. Beckwith, James J. Chou*.  Structure and Multi-State Function of the Transmembrane Electron Transporter CcdA. Nat Struct & Mol Biol, 2015, 22 (10), 809-14.

Qingshan Fu, Tian-Min Fu, Anthony C. Cruz, Prabuddha Sengupta, Stacy K. Thomas, Shuqing Wang, Richard M. Siegel, Hao Wu*, James J. Chou*. Structural Basis and Functional Role of Intramembrane Trimerization of the Fas/CD95 Death Receptor. Mol Cell, 2016, 61 (4), 602-13.

Kirill Oxenoid, Ying Dong, Chan Cao, Tanxing Cui, Yasemin Sancak, Andrew L. Markhard, Zenon Grabarek, Liangliang Kong, Zhijun Liu, Bo Ouyang, Yao Cong, Vamsi K. Mootha, James J. Chou*. Architecture of the mitochondrial calcium uniporter. Nature, 2016, 533 (7602), 269-73.

Jyoti Dev, Donghyun Park, Qingshan Fu, Jia Chen, Heather Jiwon Ha, Fadi Ghantous, Tobias Herrmann, Weiting Chang, Zhijun Liu, Gary Frey, Michael S. Seaman, Bing Chen*, James J Chou*. Structural Basis for Membrane Anchoring of HIV-1 Envelope Spike. Science, 2016, 353 (6295), 172-5.

Chan Cao, Shuqing Wang, Tanxing Cui, Xun-Cheng Su*, James J. Chou*. Ion and inhibitor binding of the double-ring ion selectivity filter of the Mitochondrial Calcium Uniporter. Proc Natl Acad Sci, 2017, 114 (14), E2846-E2851.

Alessandro Piai, Jyoti Dev, Qingshan Fu, James J Chou*. Stability and Water Accessibility of the Trimeric Membrane Anchors of the HIV-1 Envelope Spikes. J Am Chem Soc, 2017, 139 (51), 18432–5.

Qingshan Fu, Md Munan Shaik, Yongfei Cai, Fadi Ghantous, Alessandro Piai, Hanqin Peng, Sophia Rits-Volloch, Zhijun Liu, Stephen C. Harrison, Michael S. Seaman, Bing Chen*, James J. Chou*. Structure of the membrane proximal external region of HIV-1 envelope glycoprotein. Proc Natl Acad Sci, 2018, 115 (38), E8892-E8899.

Wen Chen, Yongfei Cai, Qingshan Fu, Bing Chen, Junling Guo*, James J. Chou*. Unidirectional presentation of membrane proteins in nanoparticle-supported liposomes. Angew Chem Int Ed Engl, 2019, 58 (29), 9866-70.

Liqiang Pan, Tian-Min Fu, Wenbin Zhao, Linlin Zhao, Wen Chen, Chixiao Qiu, Wenhui Liu, Zhijun Liu, Alessandro Piai, Qingshan Fu, Shuqing Chen, Hao Wu*, James J Chou*. Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling. Cell, 2019, 176 (6), 1477-89.

Qingshan Fu, Alessandro Piai, Wen Chen, Ke Xia, James J. Chou*. Structure determination protocol for transmembrane domain oligomers. Nat Protoc, 2019, 14 (8), 2483-2520.

Liqiang Pan, Chan Cao, Changqing Run, Liujuan Zhou, James J. Chou*. DNA-Mediated Assembly of Multispecific Antibodies for T Cell Engaging and Tumor Killing. Adv Sci, 2019, 7 (2), 1900973.

Linlin Zhao, Qingshan Fu, Liqiang Pan, Alessandro Piai, James J. Chou*. The Diversity and Similarity of Transmembrane Trimerization of TNF Receptors. Front Cell Dev Biol, 2020, 8, 569684.

Alessandro Piai, Qingshan Fu, Yongfei Cai, Fadi Ghantous, Tianshu Xiao, Md Munan Shaik, Hanqin Peng, Sophia Rits-Volloch, Wen Chen, Michael S. Seaman, Bing Chen*, James J. Chou*. Structural basis of transmembrane coupling of the HIV-1 envelope glycoprotein. Nat Comm, 2020, 11 (1), 2317.

Alessandro Piai, Qingshan Fu, Amanda K. Sharp, Beatrice Bighi, Anne M. Brown*, James J. Chou*. NMR model of the entire membrane-interacting region of HIV-1 fusion protein and its perturbation of membrane morphology. J Am Chem Soc, 2021, 143(17), 6609-6615.

Qingshan Fu, James J. Chou*. A Trimeric Hydrophobic Zipper Mediates the Intramembrane Assembly of SARS-CoV-2 Spike. J Am Chem Soc, 2021, 143 (23), 8543–6.

Gang Du, Linlin Zhao, Yumei Zheng, Anissa Belfetmi, Tiantian Cai, Boying Xu, Karen Heyninck, Kim Van Den Heede, Marie-Ange Buyse, Pietro Fontana, Michael Bowman, Lih-Ling Lin, Hao Wu*, James J. Chou*. Autoinhibitory structure of preligand association state implicates a new strategy to attain effective DR5 receptor activation. Cell Res, 2023, 33, 131–146.