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2024

1. Zhao W.B., Liu K.E., Fan Y., Zhao Q.Y., Tao Y.Q., Zhang M.W., Gan L.H., Yu W.B., Sun B., Li D., Liu C.*, Wang J.*, Cryo-EM structures reveal variant Tau amyloid fibrils between the rTg4510 mouse model and sporadic human tauopathies. Cell Discov., 2024.

 

2. Jiang Y.Q., Gu J.G., Niu X.D., Hu J.J., Zhang Y.Z., Li D., Tang Y.D., Liu C.*, Li Z.J.*, Phosphorylation-Regulated Dynamic Phase Separation of HIP-55 Protects Against Heart Failure. Circulation., 2024.

 

3. Hou S., Hu J.J., Yu Z.W., Li D, Liu C.*, Zhang Y.*, Machine learning predictor PSPire screens for phase-separating proteins lacking intrinsically disordered regions. Nat Commun., 2024.


2023

1. Bai Y.L., Zhang S.N., Dong H., Liu Y., Liu C.*, Zhang X.*, Advanced Techniques for Detecting Protein Misfolding and Aggregation in Cellular Environments. Chem Rev., 2023.

 

2. Li D.*, Liu C.*, Molecular rules governing the structural polymorphism of amyloid fibrils in neurodegenerative diseases. Structure., 2023.

 

3. Lai Y., Zhao C.Y., Tian Z.Q., Wang C.C.¶, Fan J.Q.¶, Hu X., Tu J., Li T.H., Leitz Jeremy., Pfuetzne R.A., Liu Z.T., Zhang S.N., Su Z.M., Burré J., Li D., Südhof Thomas.C., Zhu Z.J., Liu C.*, Brunger Axel.T.*, Diao J.J.*, Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering. Proc Natl Acad Sci U S A., 2023.

 

4. Li D.N., Ma Y.Y., Xia W.C., Tao Y.Q., Zhang Y.L., Zhang H., Li D., Dai B.*, Liu C.*, Creating an Amyloid 'Kaleidoscope' Using Short Iodinated Peptides. Angew Chem Int Ed Engl., 2023.

 

5. Wang F.H., Xia W.C., Zhang M.M., Wu R.R., Song X.L., Hao Y., Feng Y.H., Zhang L.W., Li D., Kang W.Y., Liu C.*, Liu L.*, Engineering of antimicrobial peptide fibrils with feedback degradation of bacterial-secreted enzymes. Chem Sci., 2023.

 

6. Wang X.Y., Zhang S.N., Zhang J.C., Wang Y.M., Jiang X.Y., Tao Y.Q., Li D., Zhong C.*, Liu C.*, Rational design of functional amyloid fibrillar assemblies. Chem Soc Rev., 2023.

 

7. Xiang J., Tao Y.Q., Xia Y.Y., Luo S.L., Zhao Q.Y., Li B.W., Zhang X.Q., Sun Y.P., Xia W.C., Zhang M.M., Kang S.S., Ahn E.H., Liu X., Xie F., Guan Y.H., Yang J.J., Bu L,H., Wu S.X., Wang X.C., Cao X.B., Liu C., Zhang Z.T.*, Li D.*, Ye K.Q.*, Development of an α-synuclein positron emission tomography tracer for imaging synucleinopathies. Cell., 2023.

 

8. Tao Y.Q., Xia W.C., Zhao Q.Y., Xiang H.J., Han C., Zhang S.Q., Gu W., Tang W.J, Li Y., Tan L., Li D.*, Liu C.*, Structural mechanism for specific binding of chemical compounds to amyloid fibrils. Nat Chem Biol., 2023.

 

9. Zhao Y.N.¶, Zheng Q.Y., Hong Y.J., Gao Y., Hu J.J., Lang M.J., Zhang H.F., Zhou Y., Luo H., Zhang X., Sun H., Yan X.X., Huang T., Wang Y.J., Xu H., Liu C., Wang X.*, β2-Microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer's disease model mice. Nat Neurosci., 2023.


10. Zhang H., Gu J.G., Zhang Y.L., Guo H.Z., Zhang S.N., Song J., Liu C., Wang L.*, Li D.*, Dai B.*, Graphene Quantum Dots Modulate Stress Granule Assembly and Prevent Abnormal Phase Transition of Fused in Sarcoma Protein. ACS Nano., 2023.

 

11. Xu Q.H., Ma Y.Y., Sun Y.P., Li D., Zhang X., Liu C.*, Protein amyloid aggregate: Structure and function. Aggregate., 2023.

 

12. Yang Z.F., Wang Y., Wei M., Li S., Jia C.C., Cheng C., Nusaif M., Zhang J., Liu C., Le W.D.*, Intrastriatal injection of Parkinson's disease intestine and vagus lysates initiates α-synucleinopathy in rat brain. Cell Death Dis., 2023.

 

13. Li X., Lv P., Du Y.F., Xing C.*, Liu C.*, Emerging roles of O-glycosylation in regulating protein aggregation, phase separation, and functions. Curr Opin Chem Biol., 2023.

 

14. Wang F.R., Jin T., Li H.Y., Long H.F., Liu Y., Jin S., Lu Y.Y., Peng Y.H., Liu C., Zhao L.H.*, Wang X.H.*, Cannabidivarin alleviates α-synuclein aggregation via DAF-16 in Caenorhabditis elegans. FASEB J., 2023.

 

15. Zhang S.N., Li J., Xu Q.H., Xia W.C., Tao Y.Q., Shi C.W., Li D., Xiang S.Q.*, Liu C.*, Conformational Dynamics of an α-Synuclein Fibril upon Receptor Binding Revealed by Insensitive Nuclei Enhanced by Polarization Transfer-Based Solid-State Nuclear Magnetic Resonance and Cryo-Electron Microscopy. J Am Chem Soc., 2023.

 

16. Wang Y., Ling X.B., Zhang C., Zou J., Luo B.N., Luo Y.B., Jia X.Y., Jia G.W., Zhang M.H., Hu J.C., Liu T., Wang Y.F.Y., Lu K.F., Li D., Ma J.B.*, Liu C.*, Su Z.M.*, Modular characterization of SARS-CoV-2 nucleocapsid protein domain functions in nucleocapsid-like assembly. Mol Biomed., 2023.


2022

1. Long H.F., Zeng S.Y., Sun Y.P., Liu C.*, Biochemical and biophysical characterization of pathological aggregation of amyloid proteins. Biophysics Reports., 2022.

 

2. Li Y.C., Gu J.G., Liu C.*, Li D.*, A high-throughput method for exploring the parameter space of protein liquid-liquid phase separation. Cell Reports Physical Science., 2022.

 

3. Fan Y., Zhao Q.Y., Xia W.C., Tao Y.Q., Yu W.B., Chen M.J., Liu Y.Q., Zhao J., Sun Y.P., Si C.F., Zhang S.Q., Zhang Y.Y., Li W.S., Liu C.*, Wang J.*, Li D.*, Generic amyloid fibrillation of TMEM106B in patient with Parkinson's disease dementia and normal elders. Cell Research., 2022.

 

4. Zhu S.B., Gu J.G., Yao J.J., Li Y.C., Zhang Z.T., Xia W.C., Wang Z., Gui X.R., Li L.T., Li D., Zhang H.*, Liu C.*, Liquid-liquid phase separation of RBGD2/4 is required for heat stress resistance in Arabidopsis. Developmental Cell., 2022.

 

5. Zhang S.Q., Dong H., Bian J., Li D., Liu C.*, Targeting amyloid proteins for clinical diagnosis of neurodegenerative diseases. Fundamental Research., 2022.

 

6. Li X., Zhang S.Q., Liu Z.T., Tao Y.Q., Xia W.C., Sun Y.P., Liu C., Le W.D., Sun B., Li D.*, Subtle change of fibrillation condition leads to substantial alteration of recombinant Tau fibril structure. iScience., 2022.

 

7. Huang C.A., Lu J.X., Ma X.J., Qiang J.L., Wang C.C., Liu C., Fang Y.S., Zhang Y.Y., Li D.*, Zhang S.N.*, The mouse nicotinamide mononucleotide adenylyltransferase chaperones diverse pathological amyloid client proteins. J Biol Chem., 2022.

 

8. He H., Yang W., Su N., Zhang C.K., Dai J.N., Han F., Singhai M., Bai W.J., Zhu X.L., Zhu J., Liu Z., Xia W.C., Liu X.T., Zhang C.H., Jiang K., Huang W.H., Chen D., Wang Z.Y., He X.Y., Kirchhoff F., Li Z.Y., Liu C., Huan J.N., Wang X.H., Wei W., Wang J.,Augustin H.G., Hu J.H.*, Activating NO-sGC crosstalk in the mouse vascular niche promotes vascular integrity and mitigates acute lung injury. J Exp Med., 2023.

 

9. Li Y.C., Gu J.G., Liu C., Li D.*, A High-Throughput Method to Profile Protein Liquid-Liquid Phase Separation. Methods in Molecular Biology., 2022.

 

10. Song Y.X., Dai B., Wang Y., Wang Y., Liu C., Gourdon P., Liu L.*, Wang K.T.*, Dong M.D.*, Identifying Heterozipper β-Sheet in Twisted Amyloid Aggregation. Nano Lett., 2022.

 

11. Li D.*, Liu C.*, Conformational strains of pathogenic amyloid proteins in neurodegenerative diseases. Nat Rev Neurosci., 2022.

 

12. Wang Q., Li Z.X., Zhang S.Q., Li Y.C., Wang Y., Fang Z., Ma Y.N., Liu Z., Li D., Liu C.*, Ye M.L.*, Global profiling of arginine dimethylation in regulating protein phase separation by a steric effect-based chemical-enrichment method. Proc. Natl. Acad. Sci. U S A., 2022.

 

13. Li Y.C., Lu S.Y., Gu J.G., Xia W.C., Zhang S.N., Zhang S.Q., Wang Y., Zhang C., Sun Y.P., Lei J., Liu C., Su Z.M.*, Yang J.T.*, Peng X.Z.*, Li D.*, SARS-CoV-2 impairs the disassembly of stress granules and promotes ALS-associated amyloid aggregation. Protein Cell., 2022.

 

14. Fan Y., Sun Y.P., Yu W.B., Tao Y.Q., Xia W.C., Liu Y.Q., Zhao Y.Q., Tang Y.L., Sun Y.M., Liu F.T., Cao Q., Wu J.J., Liu C., Wang J.*, Li D.*, Conformational change of α-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson’s disease. Structure., 2022.

 

15. Li D.*, Liu C.*, Spatiotemporal dynamic regulation of membraneless organelles by chaperone networks. Trends in Cell Biology., 2021.


16. Li Y.C., Gu J.G., Wang C., Hu J.J., Zhang S.Q., Liu C., Zhang S.N., Fang Y.S., Li D.*, Hsp70 exhibits a liquid-liquid phase separation ability and chaperones condensed FUS against amyloid aggregation. iScience, 2022, 25(6).


17. Wang L.Q., Ma Y.Y., Yuan H.Y., Zhao K., Zhang M.Y., Wang Q., Huang X., Dai B., Chen J., Li D., Zhang D.L., Wang Z.Z., Zou L.Y., Yin P., Liu C.*, Liang Y.*, Cryo-EM structure of an amyloid fibril formed by full-length human SOD1 reveals its conformational conversion. Nature communications, 2022, 13(1).


18. Zhao Q.Y., Tao Y.Q., Zhao K., Ma Y.Y., Xu Q.H., Liu C., Zhang S.N., Li D.*, Structural insights of Fe 3+ induced α-synuclein fibrillation in Parkinson's disease. Journal Molecular Biology, 2022.


19. Gao C., Gu J.G., Zhang H., Jiang K., Tang L.L., Liu R., Zhang L., Zhang P.F., Liu C.*, Dai B.*, Song H.*, Hyperosmotic-stress-induced liquid-liquid phase separation of ALS-related proteins in the nucleus. Cell Reports, 2022, 40(3).


20. Tao Y.Q., Sun Y.P., Lv S.R., Xia W.C., Zhao K., Xu Q.H., Zhao Q.Y., He L., Wang Y., Liu C.*, Li D.*, Heparin induces α-synuclein to form new fibril polymorphs with attenuated neuropathology. Nature communications, 2022, 13(1).


21. Guo J.L., Zhao Y.L., Zhang Q., Feng Y., Zhang X., Wang T., Liu C., Ma H.H., Sun B.*, Stochastically multimerized ParB orchestrates DNA assembly as unveiled by single-molecule analysis. Nucleic Acids Research, 2022, 50(16).


22. Teng W., Hu J.J., Li Y.N., Bi L.L., Guo X.S., Zhang X., Li D., Hou X.M., Modesti M., Xi X.G., Liu C.*, Sun B.*, Bloom Syndrome Helicase Compresses Single‐Stranded DNA into Phase‐Separated Condensates. Angewandte Chemie, 2022, 61(39).


23. Zhang S.N., Zhu Y., Lu J.X., Liu Z.Y., Lobato A.G., Zeng W., Liu J.Q., Zeng S.Y., Liu C., Liu J., He Z.H., Zhai R.G.*, Li D.*, Specific binding of Hsp27 and phosphorylated Tau mitigates abnormal Tau aggregation-induced pathology. Elife, 2022.


24. Lu S., Hu J.J., Arogundade O.A., Goginashvili A., Vazquez-Sanchez S., Diedrich J.K., Gu J.G., Blum J., Oung S., Ye Q.Z., Yu H.Y., Ravits J., Liu C., Yates J.R., Cleveland D.W.*, Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition. Nature Cell Biology, 2022, 24(9).


25. Li J., Xie J.F., Godec A., Weninger K.R., Liu C., Smith J.C., Hong L.*, Non-ergodicity of a globular protein extending beyond its functional timescale. Chemical Science, 2022, 13(33).


26. Long H.F., Zhang S.N., Zeng S.Y., Tong Y.L., Liu J., Liu C.*, Li D.*, Interaction of RAGE with α-synuclein fibrils mediates inflammatory response of microglia. Cell Reports, 2022, 40(12).


27. Li, D.*, Liu, C.*, Spatiotemporal dynamic regulation of membraneless organelles by chaperone networks. Trends in Cell Biology, 2021, 32(1).


28. Fan, Y., Zhao, Q.Y., Xia, W.C., Tao, Y.Q., Yu, W.B., Chen, M.J., Liu, Y.Q., Zhao, J., Sun, Y.P., Si, C.F., Zhang, S.Q., Zhang, Y.Y., Li, W.S., Liu, C.*, Wang J.*, Li D.*, Generic amyloid fibrillation of TMEM106B in patient with Parkinson's disease dementia and normal elders. Cell Research, 2022.


29. Huang, C.A., Lu, J.X., Ma, X.J., Qiang, J.L., Wang, C.C., Liu, C., Fang, Y.S., Zhang, Y.Y., Li, D.*, Zhang, S.N.*, The mouse nicotinamide mononucleotide adenylyltransferase chaperones diverse pathological amyloid client proteins. Journal of Biological Chemistry, 2022, 298(5).


30. Li, Y.C., Lu, S.Y., Gu, J.G., Xia, W.C., Zhang, S.N., Zhang, S.Q., Wang, Y., Zhang, C., Sun, Y.P., Lei, J., Liu, C., Su, Z.M.*, Yang, J.T.*, Peng, X.Z.*, Li, D.*, SARS-CoV-2 impairs the disassembly of stress granules and promotes ALS-associated amyloid aggregation. Protein Cell, 2022, 1-13.


31. Li, Y.C., Gu, J.G., Liu, C.*, Li, D.*, A high-throughput method for exploring the parameter space of protein liquid-liquid phase separation. Cell Reports Physical Science, 2022.


32. Zhu, S.B., Gu, J.G., Yao, J.J., Li, Y.C., Zhang, Z.T., Xia, W.C., Wang, Z., Gui, X.R., Li, L.T., Li, D., Zhang, H.*, Liu, C.*, Liquid-liquid phase separation of RBGD2/4 is required for heat stress resistance in Arabidopsis. Developmental Cell, 2022, 57(5).


33. Song, Y.X., Dai, B., Wang, Y., Wang, Y., Liu, C., Gourdon, P., Liu, L.*, Wang, K.T.*, Dong, M.D.*, Identifying Heterozipper β-Sheet in Twisted Amyloid Aggregation. Nano Letters, 2022, 22(9).


34. Long, H.F., Zeng, S.Y., Sun, Y.P., Liu, C.*, Biochemical and biophysical characterization of pathological aggregation of amyloid proteins. Biophysics Reports, 2022, 8(1).


35. Long, H.F., Zeng, S.Y., Li, D.*, Cellular and animal models to investigate pathogenesis of amyloid aggregation in neurodegenerative diseases. Biophysics Reports, 2022, 8(1).


36.Li, D.*, Liu, C.*, Conformational strains of pathogenic amyloid proteins in neurodegenerative diseases. Nature Reviews Neuroscience, 2022, 23(9).


2021

1. Liu, D.L., Wei, Q.J., Xia, W.C., He, C.D., Zhang, Q.K., Huang, L., Wang, X.Y., Sun, Y.P., Ma, Y.Y., Zhang, X.H., Wang, Y., Shi, X.M., Liu, C.*, Dong, S.W.*, O-Glycosylation Induces Amyloid-β To Form New Fibril Polymorphs Vulnerable for Degradation. Journal of the American Chemical Society, 2021, 143(48).


2. Sun, Y.P., Long, H.F., Xia, W.C., Wang, K., Zhang, X., Sun, B., Cao, Q., Zhang, Y.Y., Dai, B., Li, D., Liu, C.*, The hereditary mutation G51D unlocks a distinct fibril strain transmissible to wild-type α-synuclein. Nature communications, 2021, 12(1).


3. Wang, L.Q., Zhao, K., Yuan, H.Y., Dang, H.B., Ma, Y.Y., Wang, Q., Wang, C., Sun, Y.P., Chen, J., Li, D., Zhang, D.L., Yin, P., Liu, C.*, Liang Y.*, Genetic prion disease-related mutation E196K displays a novel amyloid fibril structure revealed by cryo-EM. Science Advances, 2021, 7(37).


4. Sun, Y.P., Zhang, S.Q., Hu, J.J., Tao, Y.Q., Xia, W.C., Gu, J.G., Li, Y.C., Cao, Q., Li, D., Liu, C.*, Molecular structure of an amyloid fibril formed by FUS low-complexity domain. iScience, 2021, 25(1).


5. Li, D.*; Liu, C.*, Hierarchical chemical determination of amyloid polymorphs in neurodegenerative disease. Nature Chemical Biology, 2021, 17(3), 237-245.


6. Tao, Y.Q.; Xie, J.F.; Zhong, Q.L.; Wang, Y.Y.; Zhang, S.N; Luo, F.; Wen, F.C.; Xie, J.J.; Zhao, J.W.; Sun, X.O.; Long, H.F.; Ma, J.F.; Zhang, Q.; Long, J.G.; Fang, X.Y.; Lu, Y.; Li, D.; Li, M.; Zhu, J.D.; Sun, B.; Li, G.H.*; Diao, J.J.*; Liu, C.*, A novel partially-open state of SHP2 points to a "multiple gear" regulation mechanism. Journal of Biological Chemistry, 2021, 296, 100538.


7. Wu, X.L.; Ma, Y.Y.; Zhao, K.; Zhang, J.; Sun, Y.P.; Li, Y.C.; Dong, X.Q.; Hu, H.; Liu, J.; Wang, J.; Zhang, X.; Li, B.; Wang, H.Y.; Li, D.; Sun, B.; Lu, J.X.*; Liu, C.*, The structure of a minimum amyloid fibril core formed by necroptosis-mediating RHIM of human RIPK3. Proceedings of the National Academy of Sciences of the United States of America, 2021, 118(14).


8. Long, H.F.; Zheng, W.T.; Liu, Y.; Sun, Y.P.; Zhao, K.; Liu, Z.Y.; Xia, W.C.; Lv, S.R.; Liu, Z.T.; Li, D.; He, K.W.*; Liu, C.*, Wild-type α-synuclein inherits the structure and exacerbated neuropathology of E46K mutant fibril strain by cross-seeding. Proceedings of the National Academy of Sciences of the United States of America, 2021, 118(20).


9. Zhang, S.N.; Liu, Y.Q.; Jia, C.Y.; Lim, Y.J.; Feng, G.Q.; Xu, E.Q.; Long, H.F.; Yasuyoshi Kimura; Tao, Y.Q.; Zhao, C.Y.; Wang, C.C.; Liu, Z.Y.; Hu, J.J.; Ma, M.R.; Liu, Z.J.; Lin, J.; Li, D.; Wang, R.X.; Valina L Dawson; Ted M Dawson*; Li, Y.M.*; Mao, X.B.*; Liu, C.*, Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America, 2021, 118(26).


10. Gu, J.G.; Wang, C.; Hu, R.F.; Li, Y.C.; Zhang, S.N.; Sun, Y.P.; Wang, Q.Q.; Li, D.; Fang, Y.S.*; Liu, C.*, Hsp70 chaperones TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation. Cell Research, 2021.

 

2020

1.    Li, D.*; Liu, C.* , Structural diversity of amyloid fibrils and advances intheir structure determination. Biochemistry 2020, 59(5), 639-646.

 

2.    Zhao, K.; Li, Y.; Liu, Z.; Long, H.; Zhao,C.; Luo, F.; Sun, Y.; Tao, Y.; Su, X.; Li; D.*; Li X.M.*; Liu C.*, Parkinson’sdisease associated mutation E46K of α-synuclein triggers the formation of adistinct fibril structure. Nature communications 2020, 11(1), 1-9.

 

3.    Zhang, H.*; Ji, X.*; Li, P.*; Liu, C.* ; Lou, J.*; Wang, Z.; Wen, W.*;Xiao, Y.; Zhang, M.*; Zhu, X.*, Liquid-liquid phase separation in biology:mechanisms, physiological functions and human diseases. Science China Life Sciences 2020, 63 (7), 953-985.

 

4.    Wang, L.; Zhao, K.; Yuan, H.-Y.; Wang, Q.; Guan,Z.; Tao, J.; Li, X.; Sun, Y.; Yi, C.; Chen, J.; Li D.; Zhang D.; Yin P.; LiuC.*; Liang Y.*, Cryo-EM structure of an amyloid fibril formed by full-lengthhuman prion protein. Nature Structural & Molecular Biology 2020, 1-5.

 

5.    Wang, C.; Tu, J.; Zhang, S.; Cai, B.; Liu,Z.; Hou, S.; Zhong, Q.; Hu, X.; Liu, W.; Li, G.; Liu Z.; He L.; Diao J.; Zhu J.;Li D.*; Liu C.*; Different regions of synaptic vesicle membrane regulate VAMP2conformation for the SNARE assembly. Nature communications 2020, 11(1), 1-12.

 

6.    Wang, C.; Duan, Y.; Duan, G.; Wang, Q.; Zhang,K.; Deng, X.; Qian, B.; Gu, J.; Ma, Z.; Zhang, S.; Guo L.; Liu C.*; Fang Y.*,Stress induces dynamic, cytotoxicity-antagonizing TDP-43 nuclear bodies viaparaspeckle lncRNA NEAT1-mediated liquid-liquid phase separation. MolecularCell 2020,443-458.

 

7.    Sun, Y.; Hou, S.; Zhao, K.; Long, H.; Liu,Z.; Gao, J.; Zhang, Y.; Su, X.; Li, D.*; Liu,C.* , Cryo-EM structure of full-length α-synuclein amyloid fibril withParkinson’s disease familial A53T mutation.

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