2022

• RIPK1 and RIPK3 form mosaic necrosomes. Weiwei Qi, Junying Yuan. Nat Cell Biol., 2022 Apr;24(4):406-407.

• Visualizing Endogenous Necrosomes in Necrosomes by In Situ Proximity Ligation Assay. Wei Liang, Junying Yuan. Curr Protoc., 2022 Feb;2(2):e388.

• PINK1 mediates neuronal survival in monkey. Zhiyu Sun, Jiangyu Ye, Junying Yuan. Protein Cell., 2022 Jan;13(1):4

2021

• Genetic Regulation of RIPK1 and Necroptosis. Daichao Xu, Chengyu Zou, Junying Yuan. Annu Rev Genet., 2021 Nov 23;55:235-263.

• NEK1-mediated retromer trafficking promotes blood-brain barrier integrity by regulating glucose metabolism and RIPK1 activation. Huibing Wang, Weiwei Qi , Chengyu Zou, Zhangdan Xie, Mengmeng Zhang, Masanori Gomi Naito, Lauren Mifflin, Zhen Liu, Ayaz Najafov, Heling Pan, Bing Shan, Ying Li, Zheng-Jiang Zhu, Junying Yuan. Nat Commun., 2021 Aug 10;12:4826.

• SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation. Gang Xu, Ying Li, Shengyuan Zhang, Haoran Peng, Yunyun Wang, Dekang Li, Taijie Jin, Zhuohao He, Yilun Tong, Chunting Qi, Guowei Wu, Kangyun Dong, Jizhou Gou, Yang Liu, Tongyang Xiao, Jing Qu, Liang Li, Liang Liu, Ping Zhao, Zheng Zhang, Junying Yuan. Cell Res., 2021 Oct 18; 31:1230.

• Quantitative analysis of phosphoproteome in necroptosis reveals a role of TRIM28 phosphorylation in promoting necroptosis-induced cytokine production. Rui Zu, Zhen Yu, Jing Zhao, Xiaojuan Lu, Wei Liang, Le Sun, Chenfang Si, Kezhou Zhu , Tian Zhang, Ganquan Li, Mengmeng Zhang, Yaoyang Zhang, Nan Liu, Junying Yuan, Bing Shan. Cell Death Dis., 2021 Oct 23;12:994

• Necroptosis activates UPR sensors without disrupting their binding with GRP78. Wei • Liang, Weiwei Qi, Yang Geng, Linhan Wang, Jing Zhao, Kezhou Zhu, Guowei Wu, Zairong Zhang, Heling Pan, Lihui Qian, Junying Yuan.  Proc Natl Acad Sci, 2021 Aug 8; 118(39):e2110476118

•  Discovery of a cooperative mode of inhibiting RIPK1 kinase. Huyan Meng, Guowei Wu, Xinsuo Zhao, Anhui Wang, Dekang Li, Yilun Tong, Taijie Jin, Ye Cao, Bing Shan, Shichen Hu, Ying Li, Lifeng Pan, Xiaoxu Tian, Ping Wu, Chao Peng, Junying Yuan, Guohui Li, Li Tan, Zhaoyin Wang, Ying Li. Cell Discovery, 2021 Jun 1;7(1):41. 

•  Caspase inhibition prolongs inflammation by promoting a signaling complex with activated RIPK1. Xinyue Huang, Shuixia Tan, Yanxia Li, Shuangyi Cao, Xingyan Li, Heling Pan, Bing Shan, Lihui Qian, and Junying Yuan. (2021). Journal of Cell Biology, 2021 Jun 7;220(6):e202007127.

2020

• Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners. Xingyan Li, Mengmeng Zhang, Xinyue Huang, Wei Liang, Ganquan Li, Xiaojuan Lu, Yanxia Li, Heling Pan, Linyu Shi, Hong Zhu, Lihui Qian, Bing Shan & Junying Yuan. Nature Communications, 2020 Dec 11;11(1):6364.

• Modulating TRADD to restore cellular homeostasis and inhibit apoptosis. Daichao Xu, H. Z., Minzhi Jin, Hong Zhu, Bing Shan, Jiefei Geng, Slawomir A. Dziedzic,  Palak Amin, Lauren Mifflin, Masanori Gomi Naito, Ayaz Najafov, Jing Xing, Lingjie Yan, Jianping Liu, Ying Qin, Xinqian Hu, Huibing Wang, Mengmeng Zhang, Vica Jean Manuel, Li Tan, Zhuohao He, Zhenyu J. Sun, Virginia M. Y. Lee, Gerhard Wagner, Junying Yuan*. Nature. 587(7832):133-138. 

• Hepatocyte-Specific TAK1 Deficiency Drives RIPK1 Kinase-dependent Inflammation to Promote Liver Fibrosis and Hepatocellular Carcinoma. Shuixia Tana,b,1, Jing Zhaoa,b,1, Ziyu Suna,b, Shuangyi Caoa, Kongyan Niua, Yedan Zhonga, Han Wanga,b, Linyu Shia,Heling Pana, Junhao Hua, Lihui Qiana, Nan Liua,2, and Junying Yuanc,2. Proc Natl Acad Sci U S A.,2020 Jun 23; 117 (25) 14231-14242.

2019

• Dominant RIPK1 Cleavage Site Variants Cause an Autoinflammatory Disease with Cell-type Specific Dysregulation of Inflammation and Cell Death. Panfeng Tao1, 12, Jinqiao Sun1, 12, Zheming Wu2, 12, Shihao Wang1, 12, Jun Wang1, 12, Heling Pan2, 12, Renkui Bai3, Jiahui Zhang1, Ying Wang1, Pui Y. Lee4, Wenjing Ying1, Qinhua Zhou1, Jia Hou1, Wenjie Wang1, BijunSun1, Mi Yang1, Danru Liu1，Huan Han1, Zhaohui Yang1, Ran Fang1, Natalie Deuitch5, Yuan Zhang6, Dilan Dissanayake7, Katrina Haude3, Kirsty McWalter3, Roadhouse Chelsea8, Jennifer J. MacKenzie8, 9, Ronald Laxer7, Ivona Aksentijevich10, Xiaomin Yu1,*, Xiaochuan Wang1,*, Junying Yuan11,*, Qing Zhou1. Nature, 577:109–114.

• Chaperone-mediated autophagy is involved in the execution of ferroptosis. Wu Z,  Geng Y, Lu X, Shi Y, Wu G, Zhang M, Shan B, Pan H, Yuan J. Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2996-3005.

2018

• Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis. Meng H, Liu Z, Li X, Wang H, Jin T, Wu G, Shan B, Christofferson DE, Qi C, Yu Q, Li Y, Yuan J. Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E2001-E2009.

• Necroptosis in development and diseases. Shan B, Pan H, Najafov A, Yuan J. Genes Dev. 2018 Mar 1;32(5-6):327-340.

• Necroptosis promotes cell-autonomous activation of proinflammatory cytokine gene expression. Zhu K, Liang W, Ma Z, Xu D, Cao, S, Lu X, Liu N, Shan B, Qian L, Yuan J. Cell Death & Disease. 2018 May 1;9(5):500.

• TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging. Xu D, Jin T, Zhu H, Chen H, Ofengeim D, Zou C, Mifflin L, Pan L, Amin P, Li W, Shan B, Naito MG, Meng H, Li Y, Pan H, Aron L, Adiconis X, Levin JZ, Yankner BA, Yuan J. Cell. 2018 Sep 6;174(6):1477-1491.

2017

• USP25 regulates Wnt signaling by controlling the stability of tankyrases. Xu D, Liu J, Fu T, Shan B, Qian L, Pan L, Yuan J. Genes Dev. 2017 May 15;31(10):1024-1035.

• SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination. Wei R1, Xu LW, Liu J, Li Y, Zhang P, Shan B, Lu X, Qian L, Wu Z, Dong K, Zhu H, Pan L, Yuan J, Pan H. Genes Dev. 2017 Jul 1,31(11):1162-1176.

• Systematic Metrics Depicting Cell Death Kinetics. Li Y, Yuan J. Cell Chem Biol. 2017 Jul 20; 24(7):785-786.

• Small molecule probes for cellular death machines. Li Y, Qian L, Yuan J. Curr Opin Chem Biol. 2017 Aug; 39:74-82.

• PELI1 functions as a dual modulator of necroptosis and apoptosis by regulating ubiquitination of RIPK1 and mRNA levels of c-FLIP. Wang H, Meng H, Li X, Zhu K, Dong K, Mookhtiar AK, Wei H, Li Y, Sun SC, Yuan J. Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):11944-11949.

2016

• Roles of Caspases in Necrotic Cell Death. Yuan J, Najafov A, Py BF. Cell. 2016 Dec 15;167(7):1693-1704.

• USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1. Xu D, Shan B, Sun H, Xiao J, Zhu K, Xie X, Li X, Liang W, Lu X, Qian L, Yuan J. Genes Dev. 2016 Aug 1;30(15):1718-30.

2015

• Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system. Xu D, Shan B, Lee BH, Zhu K, Zhang T, Sun H, Liu M, Shi L, Liang W, Qian L, Xiao J, Wang L, Pan L, Finley D, Yuan J. Elife. 2015 Nov 2

• Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death. Xia HG, Najafov A, Geng J, Galan-Acosta L, Han X, Guo Y, Shan B, Zhang Y, Norberg E, Zhang T, Pan L, Liu J, Coloff JL, Ofengeim D, Zhu H, Wu K, Cai Y, Yates JR, Zhu Z, Yuan J, Vakifahmetoglu-Norberg H. J Cell Biol. 2015 Aug 31;210(5):705-16.

• G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L. Zhang T, Dong K, Liang W, Xu D, Xia H, Geng J, Najafov A, Liu M, Li Y, Han X, Xiao J, Jin Z, Peng T, Gao Y, Cai Y, Qi C, Zhang Q, Sun A, Lipinski M, Zhu H, Xiong Y, Pandolfi PP, Li H, Yu Q, Yuan J. Elife. 2015 Mar 30;4:e06734.

• FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation. Xiao J, Zhang T, Xu D, Wang H, Cai Y, Jin T, Liu M, Jin M, Wu K, Yuan J. Genes Dev2015 Jan 15;29(2):184-96.

• Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon. Xu D, Zhang T, Xiao J, Zhu K, Wei R, Wu Z, Meng H, Li Y, Yuan J. Autophagy 2015 Apr 3;11(4):617-28.

2014-2007

• Mitochondrial Electron Transport Chain Complex III Is Required for Antimycin A to Inhibit Autophagy. Xiuquan Ma, Mingzhi Jin, Yu Cai, Hong-guang Xia, Kai Long, Junli Liu, Qiang Yu and Junying Yuan. Chemistry & Biology. 2011 Nov; 18(11): 1474-1481.

• Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13.  Liu J, Xia H, Kim M, Xu L, Li Y, Zhang L, Cai Y, Norberg HV, Zhang T, Furuya T, Jin M, Zhu Z, Wang H, Yu J, Li Y, Hao Y, Choi A, Ke H, Ma D, Yuan J. Cell. 2011, 147, 223-234.

• Identification of a small molecule activator of novel PKCs for promoting glucose-dependent insulin secretion. Han S#, Pan H#, Zhang J, Tan L, Ma D, Yuan J, Wu JR. Cell Research. 2011 Apr;21 (4):588-99.

• Control of basal autophagy by calpain1 mediated cleavage of ATG5. Hong-guang Xia, Lihong Zhang, Gang Chen, Tao Zhang, Junli Liu, Mingzhi Jin, Xiuquan Ma, Dawei Ma, and Junying Yuan. Autophagy, 2010 Jan; 6(1): 61-66.

• A Novel Small Molecule Regulator of Guanine Nucleotide Exchange Activity of the ADP-ribosylation Factor and Golgi Membrane Trafficking. Pan H, Yu J, Zhang L, Carpenter A, Zhu H, Li L, Ma D, Yuan J. J Biol Chem., 2008 Nov 7;283 (45):31087-96.

• Small molecule regulators of autophagy identified by an image-based high-throughput screen. Zhang L, Yu J, Pan H, Hu P, Hao Y, Cai W, Zhu H, Yu AD, Xie X, Ma D, Yuan J. Proc Natl Acad Sci USA., 2007 Nov 27;104 (48):19023-8.