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2021

•  Discovery of a cooperative mode of inhibiting RIPK1 kinase. Huyan Meng, Guowei Wu, Xinsuo Zhao, Anhui Wang, Dekang Li, Yilun Tong, Taijie Jin, Ye Cao, Bing Shan, Shichen Hu, Ying Li, Lifeng Pan, Xiaoxu Tian, Ping Wu, Chao Peng, Junying Yuan, Guohui Li, Li Tan, Zhaoyin Wang, Ying Li. Cell Discovery, 2021 Jun 1;7(1):41. 

•  Caspase inhibition prolongs inflammation by promoting a signaling complex with activated RIPK1. Xinyue Huang, Shuixia Tan, Yanxia Li, Shuangyi Cao, Xingyan Li, Heling Pan, Bing Shan, Lihui Qian, and Junying Yuan. (2021). Journal of Cell Biology, 2021 Jun 7;220(6):e202007127.


2020

• Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners. Xingyan Li, Mengmeng Zhang, Xinyue Huang, Wei Liang, Ganquan Li, Xiaojuan Lu, Yanxia Li, Heling Pan, Linyu Shi, Hong Zhu, Lihui Qian, Bing Shan & Junying Yuan. Nature Communications, 2020 Dec 11;11(1):6364.

• Modulating TRADD to restore cellular homeostasis and inhibit apoptosis. Daichao Xu, H. Z., Minzhi Jin, Hong Zhu, Bing Shan, Jiefei Geng, Slawomir A. Dziedzic,  Palak Amin, Lauren Mifflin, Masanori Gomi Naito, Ayaz Najafov, Jing Xing, Lingjie Yan, Jianping Liu, Ying Qin, Xinqian Hu, Huibing Wang, Mengmeng Zhang, Vica Jean Manuel, Li Tan, Zhuohao He, Zhenyu J. Sun, Virginia M. Y. Lee, Gerhard Wagner, Junying Yuan*. Nature. 587(7832):133-138. 

• Hepatocyte-Specific TAK1 Deficiency Drives RIPK1 Kinase-dependent Inflammation to Promote Liver Fibrosis and Hepatocellular Carcinoma. Shuixia Tana,b,1, Jing Zhaoa,b,1, Ziyu Suna,b, Shuangyi Caoa, Kongyan Niua, Yedan Zhonga, Han Wanga,b, Linyu Shia,Heling Pana, Junhao Hua, Lihui Qiana, Nan Liua,2, and Junying Yuanc,2. Proc Natl Acad Sci U S A.,2020 Jun 23; 117 (25) 14231-14242.


2019

• Dominant RIPK1 Cleavage Site Variants Cause anAutoinflammatory Disease with Cell-type Specific Dysregulation of Inflammationand Cell Death. Panfeng Tao1, 12, Jinqiao Sun1, 12, Zheming Wu2, 12, ShihaoWang1, 12, Jun Wang1, 12, Heling Pan2, 12, Renkui Bai3, Jiahui Zhang1, YingWang1, Pui Y. Lee4, Wenjing Ying1, Qinhua Zhou1, Jia Hou1, Wenjie Wang1,BijunSun1, Mi Yang1, Danru Liu1,Huan Han1, ZhaohuiYang1, Ran Fang1, Natalie Deuitch5, Yuan Zhang6, Dilan Dissanayake7, KatrinaHaude3, Kirsty McWalter3, Roadhouse Chelsea8, Jennifer J. MacKenzie8, 9, RonaldLaxer7, Ivona Aksentijevich10, Xiaomin Yu1,*, Xiaochuan Wang1,*, JunyingYuan11,*, Qing Zhou1. Nature,577:109–114.

• Chaperone-mediated autophagy is involved in theexecution of ferroptosis. Wu Z,  Geng Y,Lu X, Shi Y, Wu G, Zhang M, Shan B, Pan H, Yuan J. Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2996-3005.


2018

• Death-domain dimerization-mediated activation of RIPK1 controlsnecroptosis and RIPK1-dependent apoptosis. Meng H, Liu Z, Li X, Wang H, Jin T,Wu G, Shan B, Christofferson DE, Qi C, Yu Q, Li Y, Yuan J. Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E2001-E2009.

• Necroptosis in development and diseases. Shan B, Pan H,Najafov A, Yuan J. Genes Dev. 2018Mar 1;32(5-6):327-340.

• Necroptosis promotes cell-autonomous activation ofproinflammatory cytokine gene expression. Zhu K, Liang W, Ma Z, Xu D, Cao, S,Lu X, Liu N, Shan B, Qian L, Yuan J. CellDeath & Disease. 2018 May 1;9(5):500.

• TBK1 Suppresses RIPK1-Driven Apoptosis andInflammation during Development and in Aging. Xu D, Jin T, Zhu H, Chen H, Ofengeim D, Zou C, Mifflin L, Pan L, Amin P,Li W, Shan B, Naito MG, Meng H, Li Y, Pan H, Aron L, Adiconis X, Levin JZ,Yankner BA, Yuan J. Cell. 2018 Sep6;174(6):1477-1491.


2017

• USP25 regulates Wnt signaling by controlling thestability of tankyrases. Xu D, Liu J, Fu T, Shan B, Qian L, Pan L, Yuan J. Genes Dev. 2017 May15;31(10):1024-1035.

• SPATA2 regulates the activation of RIPK1 by modulatinglinear ubiquitination. Wei R1, Xu LW, Liu J, Li Y, Zhang P, Shan B, Lu X, QianL, Wu Z, Dong K, Zhu H, Pan L, Yuan J, Pan H. Genes Dev. 2017 Jul 1,31(11):1162-1176.

• Systematic Metrics Depicting Cell Death Kinetics. Li Y,Yuan J. Cell Chem Biol. 2017 Jul 20;24(7):785-786.

• Small molecule probes for cellular death machines. Li Y,Qian L, Yuan J. Curr Opin Chem Biol.2017 Aug; 39:74-82.

• PELI1 functionsas a dual modulator of necroptosis and apoptosis by regulating ubiquitinationof RIPK1 and mRNA levels of c-FLIP. Wang H, Meng H, Li X, Zhu K, Dong K,Mookhtiar AK, Wei H, Li Y, Sun SC, Yuan J. ProcNatl Acad Sci U S A. 2017 Nov 7;114(45):11944-11949.
2016:

• Roles of Caspases in Necrotic Cell Death. Yuan J, Najafov A, Py BF. Cell. 2016 Dec15;167(7):1693-1704.

• USP14 regulates autophagy by suppressing K63ubiquitination of Beclin 1. Xu D, ShanB, Sun H, Xiao J, Zhu K, Xie X, Li X, Liang W, Lu X, Qian L, Yuan J. Genes Dev. 2016 Aug 1;30(15):1718-30.


2015:

• Phosphorylationand activation of ubiquitin-specific protease-14 by Akt regulates theubiquitin-proteasome system. Xu D, Shan B, Lee BH, Zhu K, Zhang T, Sun H, Liu M, Shi L, Liang W, QianL, Xiao J, Wang L, Pan L, Finley D, Yuan J. Elife. 2015 Nov 2

• Degradation of HK2 by chaperone-mediated autophagypromotes metabolic catastrophe and cell death. Xia HG, Najafov A, Geng J, Galan-Acosta L, Han X, Guo Y, Shan B,Zhang Y, Norberg E, Zhang T, Pan L, Liu J, Coloff JL, Ofengeim D, Zhu H, Wu K,Cai Y, Yates JR, Zhu Z, Yuan J, Vakifahmetoglu-Norberg H. J Cell Biol. 2015Aug 31;210(5):705-16.

• G-protein-coupled receptorsregulate autophagy by ZBTB16-mediated ubiquitination and proteasomaldegradation of Atg14L. Zhang T,Dong K, Liang W, Xu D, Xia H, Geng J, Najafov A, Liu M, Li Y, Han X, Xiao J,Jin Z, Peng T, Gao Y, Cai Y, Qi C, Zhang Q, Sun A, Lipinski M, Zhu H, Xiong Y,Pandolfi PP, Li H, Yu Q, Yuan J. Elife. 2015 Mar 30;4:e06734.

• FBXL20-mediated Vps34ubiquitination as a p53 controlled checkpoint inregulating autophagy and receptor degradation. Xiao J, Zhang T, Xu D, Wang H, Cai Y, Jin T, Liu M, Jin M, Wu K, YuanJ. Genes Dev2015 Jan 15;29(2):184-96.

• Modification of BECN1 by ISG15plays a crucial role in autophagy regulation by type IIFN/interferon. Xu D, Zhang T, Xiao J, ZhuK, Wei R, Wu Z, Meng H, Li Y, Yuan J. Autophagy 2015 Apr3;11(4):617-28.


2014-2007:

• Mitochondrial Electron Transport Chain Complex III IsRequired for Antimycin A to Inhibit Autophagy. Xiuquan Ma, Mingzhi Jin, Yu Cai,Hong-guang Xia, Kai Long, Junli Liu, Qiang Yu and Junying Yuan. Chemistry & Biology. 2011 Nov;18(11): 1474-1481.

• Beclin1 controls the levels of p53 by regulating thedeubiquitination activity of USP10 and USP13.  Liu J, Xia H, Kim M, Xu L, Li Y, Zhang L, CaiY, Norberg HV, Zhang T, Furuya T, Jin M, Zhu Z, Wang H, Yu J, Li Y, Hao Y, ChoiA, Ke H, Ma D, Yuan J. Cell. 2011, 147,223-234.

• Identification of a small molecule activator of novelPKCs for promoting glucose-dependent insulin secretion. Han S#, Pan H#, ZhangJ, Tan L, Ma D, Yuan J, Wu JR. CellResearch. 2011 Apr;21 (4):588-99.

• Control of basal autophagy by calpain1 mediated cleavageof ATG5. Hong-guang Xia, Lihong Zhang, Gang Chen, Tao Zhang, Junli Liu, MingzhiJin, Xiuquan Ma, Dawei Ma, and Junying Yuan. Autophagy, 2010 Jan; 6(1): 61-66.

• A Novel Small Molecule Regulator of Guanine Nucleotide ExchangeActivity of the ADP-ribosylation Factor and Golgi Membrane Trafficking. Pan H,Yu J, Zhang L, Carpenter A, Zhu H, Li L, Ma D, Yuan J. J Biol Chem., 2008 Nov 7;283 (45):31087-96.

• Small molecule regulators of autophagy identified by an image-basedhigh-throughput screen. Zhang L, Yu J, Pan H, Hu P, Hao Y, Cai W, Zhu H, Yu AD,Xie X, Ma D, Yuan J. Proc Natl Acad SciUSA., 2007 Nov 27;104 (48):19023-8.

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