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Selected publications


(1) Wang, Z., Deschenes, D.  "Enantiospecific synthesis via sequential diastereofacial and diastereotopic group selective reactions: enantiodivergent synthesis of syn-1,3-polyols."  J. Am. Chem. Soc, 1992, 114, 1090-1091.

 

(2) Wang, Z., Warder, S., Perrier, H., Grimm, E.  "A straightforward approach to the synthesis of the tricyclic core of taxanes."  J. Org. Chem. 1993, 58, 2931-2932

 

(3) Prasit, P., Wang, Z., Brideau, C., Chan, C.-C., Charleson, S., Cromlish, W., Ethier, D.,  . Evans, J. F., Ford-Hutchinson, A. W., Gauthier, J. Y.,  Gordon, R., Guay, J., Gresser, M., S. Kargman, S., Kennedy, B., Leblanc, Y., Léger, S. , Mancini, J., O'Neill, G. P., Ouellet, M, Percival, D., Perrier, H., Riendeau, D., Rodger, I. W., Tagari, P. Thérien, M., Vickers, P., Wong, E., Xu, L.-J., Young, R. N. and Zamboni, R. "Rofecoxib, [MK 966, Vioxx‚, 4-( 4'-Methylsulfonylphenyl)-3- -2 Phenyl (5H)-Furanone]: the Discovery of a Selective and Orally Active Cyclooxygenase-2 Inhibitor." Bioorg. Med. Chem. Lett. 9, 1999,: 1773-78.

 

(4) Baskin,J.M. and Wang,Z. “A mild, convenient synthesis of sulfinates and sulfonamides from alkyl and aryl halides”. Tetrahedron Lett. 43 2002: 8479-8483.

 

(5) Baskin,J.M. and Wang,Z. “An Efficient Copper Catalyst for the Formation of Sulfones from Sulfinic Acid Salts and Aryl Iodides.” Organic Letters 4,  2002: 4423-4425.

 

(6) Beaulieu, C., Wang, Z., Denis, D., Greig, G.M., Lamontagne, S., Slipetz, D., O'Neill, G.P., and Wang, J.  “Benzimidazoles as New Potent and Selective DP Antagonists for the treatment of Allergic Rhinitis”. Bioorg. Med. Chem. Lett. 14, 2004:  3195-3199.

 

(7) Beaulieu, C., Wang, Z., Guay, D., and Evans, D.A.  “A mild and efficient new synthesis of aryl sulfones from boronic acids and sulfinic acid salts”. Tetrahedron Lett. 45, 2004:  3233-3236.

 

(8) Sturino,C.F., Lachance,N., Boyd,M.J., Berthelette,C., Li,L., Roy,B., Scheigetz,J., Tsou,N.N., Bateman,K.P., Day,S.H., Levesque,J.-F., Carrière,M.-C., Denis,D., Greig,G.M., Kargman,S.L., Lamontagne,S., Mathieu,M.-C., Sawyer,N., Slipetz,D., Jones,T.R., Nicoll-Griffith,D.A., Wang,Z., O'Neill,G.P., Zamboni,R.J., Metters,K.M., and Young,R.N. (2006). “Discovery of mk-0524, a potent and selective pgd2 receptor antagonist.” Journal of Medicinal Chemistry, 50, 2007, 794-806.

 

(9) Colucci, J.; Boyd, M.; Berthelette, C.; Chiasson, J.-F.; Wang, Z.; Ducharme, Y.; Friesen, R.; Wrona, M.; Levesque, J.-F.; Denis, D.; Mathieu, M.-C.; Stocco, R.; Therien, A. G..; Clarke, P.; Rowland, S.; Xu, D.; Han, Y.  “Discovery of 4-{1-[({1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl}benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory painl.” Bioorganic & Medicinal Chemistry Letters (2010), 20(12), 3760-3763.

 

(10) Li, L.; Berthelette, C.; Chateauneuf, A.; Ouellet, M.; Sturino, C. F.; Wang, Z., “Potent and selective 5-LO inhibitor bearing benzothiophene pharmacophore: Discovery of MK-5286”, Bioorganic & Medicinal Chemistry Letters (2010), 20(24), 7440-7443.


(11) Gallant, M.; Beaulieu, C.; Berthelette, C.; Colucci, J.; Crackower, M. A..; Dalton, C.; Denis, D.; Ducharme, Y.; Friesen, R. W..; Guay, D.; Gervais, F. G.; Hamel, M.; Houle, R.; Krawczyk, C. M.; Kosjek, B.; Lau, S.; Leblanc, Y.; Lee, E. E.; Levesque, J.-F.; Mellon, C.; Molinaro, C.; Mullet, W.; O'Neill, G. P.; O'Shea, P.; Sawyer, N.; Sillaots, S.; Simard, D.; Slipetz, D.; Stocco, R.; Sorensen, D.; Truong, V. L.; Wong, E.; Wu, J.; Zaghdane, H.; Wang, Z., “Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases”, Bioorganic & Medicinal Chemistry Letters (2011), 21(1), 288-293.


(12)Zhang L, Wang Z, Wang Z, Luo F, Guan M, Xu M, Li Y, Zhang Y, Wang Z, Wang W. “A Simple and Efficient Method to Generate Dual Site-Specific Conjugation ADCs with Cysteine Residue and an Unnatural Amino Acid”, Bioconjug. Chem. 2021, 32, 6, 1094-1104.


(13)Meng H, Wu G, Zhao X, Wang A, Li D, Tong Y, Jin T, Cao Y, Shan B, Hu S, Li Y, Pan L, Tian X, Wu P, Peng C, Yuan J, Li G, Tan L, Wang Z, Li Y. “Discovery of a cooperative mode of inhibiting RIPK1 kinas”, Cell Discovery. 2021, 7, 41.


(14)Zhao X, Zeng W, Xu H, Sun Z, Hu Y, Peng B, McBride JD, Duan J, Deng J, Zhang B, Kim SJ, Zoll B, Saito T, Sasaguri H, Saido TC, Ballatore C, Yao H, Wang Z, Trojanowski JQ, Brunden KR, Lee VM, He Z. “A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injury”, Sci Transl Med. 2023 Sep 13; 15(713).


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