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2021

1. Li, D.*; Liu, C.*, Hierarchical chemical determination of amyloid polymorphs in neurodegenerative disease. Nature Chemical Biology, 2021, 17(3), 237-245.


2. Tao, Y.Q.; Xie, J.F.; Zhong, Q.L.; Wang, Y.Y.; Zhang, S.N; Luo, F.; Wen, F.C.; Xie, J.J.; Zhao, J.W.; Sun, X.O.; Long, H.F.; Ma, J.F.; Zhang, Q.; Long, J.G.; Fang, X.Y.; Lu, Y.; Li, D.; Li, M.; Zhu, J.D.; Sun, B.; Li, G.H.*; Diao, J.J.*; Liu, C.*, A novel partially-open state of SHP2 points to a "multiple gear" regulation mechanism. Journal of Biological Chemistry, 2021, 296, 100538.


3. Wu, X.L.; Ma, Y.Y.; Zhao, K.; Zhang, J.; Sun, Y.P.; Li, Y.C.; Dong, X.Q.; Hu, H.; Liu, J.; Wang, J.; Zhang, X.; Li, B.; Wang, H.Y.; Li, D.; Sun, B.; Lu, J.X.*; Liu, C.*, The structure of a minimum amyloid fibril core formed by necroptosis-mediating RHIM of human RIPK3. Proceedings of the National Academy of Sciences of the United States of America, 2021, 118(14).


4. Long, H.F.; Zheng, W.T.; Liu, Y.; Sun, Y.P.; Zhao, K.; Liu, Z.Y.; Xia, W.C.; Lv, S.R.; Liu, Z.T.; Li, D.; He, K.W.*; Liu, C.*, Wild-type α-synuclein inherits the structure and exacerbated neuropathology of E46K mutant fibril strain by cross-seeding. Proceedings of the National Academy of Sciences of the United States of America, 2021, 118(20).


5. Zhang, S.N.; Liu, Y.Q.; Jia, C.Y.; Lim, Y.J.; Feng, G.Q.; Xu, E.Q.; Long, H.F.; Yasuyoshi Kimura; Tao, Y.Q.; Zhao, C.Y.; Wang, C.C.; Liu, Z.Y.; Hu, J.J.; Ma, M.R.; Liu, Z.J.; Lin, J.; Li, D.; Wang, R.X.; Valina L Dawson; Ted M Dawson*; Li, Y.M.*; Mao, X.B.*; Liu, C.*, Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America, 2021, 118(26).


6. Gu, J.G.; Wang, C.; Hu, R.F.; Li, Y.C.; Zhang, S.N.; Sun, Y.P.; Wang, Q.Q.; Li, D.; Fang, Y.S.*; Liu, C.*, Hsp70 chaperones TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation. Cell Research, 2021.

 

2020

1.    Li, D.*; Liu, C.* , Structural diversity of amyloid fibrils and advances intheir structure determination. Biochemistry 2020, 59(5), 639-646.

 

2.    Zhao, K.; Li, Y.; Liu, Z.; Long, H.; Zhao,C.; Luo, F.; Sun, Y.; Tao, Y.; Su, X.; Li; D.*; Li X.M.*; Liu C.*, Parkinson’sdisease associated mutation E46K of α-synuclein triggers the formation of adistinct fibril structure. Nature communications 2020, 11(1), 1-9.

 

3.    Zhang, H.*; Ji, X.*; Li, P.*; Liu, C.* ; Lou, J.*; Wang, Z.; Wen, W.*;Xiao, Y.; Zhang, M.*; Zhu, X.*, Liquid-liquid phase separation in biology:mechanisms, physiological functions and human diseases. Science China Life Sciences 2020, 63 (7), 953-985.

 

4.    Wang, L.; Zhao, K.; Yuan, H.-Y.; Wang, Q.; Guan,Z.; Tao, J.; Li, X.; Sun, Y.; Yi, C.; Chen, J.; Li D.; Zhang D.; Yin P.; LiuC.*; Liang Y.*, Cryo-EM structure of an amyloid fibril formed by full-lengthhuman prion protein. Nature Structural & Molecular Biology 2020, 1-5.

 

5.    Wang, C.; Tu, J.; Zhang, S.; Cai, B.; Liu,Z.; Hou, S.; Zhong, Q.; Hu, X.; Liu, W.; Li, G.; Liu Z.; He L.; Diao J.; Zhu J.;Li D.*; Liu C.*; Different regions of synaptic vesicle membrane regulate VAMP2conformation for the SNARE assembly. Nature communications 2020, 11(1), 1-12.

 

6.    Wang, C.; Duan, Y.; Duan, G.; Wang, Q.; Zhang,K.; Deng, X.; Qian, B.; Gu, J.; Ma, Z.; Zhang, S.; Guo L.; Liu C.*; Fang Y.*,Stress induces dynamic, cytotoxicity-antagonizing TDP-43 nuclear bodies viaparaspeckle lncRNA NEAT1-mediated liquid-liquid phase separation. MolecularCell 2020,443-458.

 

7.    Sun, Y.; Hou, S.; Zhao, K.; Long, H.; Liu,Z.; Gao, J.; Zhang, Y.; Su, X.; Li, D.*; Liu,C.* , Cryo-EM structure of full-length α-synuclein amyloid fibril withParkinson’s disease familial A53T mutation.Cell Research 2020, 30(4), 360-362.

 

8.    Ma, X.; Zhu, Y.; Lu, J.; Xie, J.; Li, C.; Shin,W. S.; Qiang, J.; Liu, J.; Dou, S.; Xiao; Y.; Xiao Y.; Wang C.; Jia C.; Long H.;Yang J.; Fang Y.; Jiang L.;Zhang Y.; Zhang S.; Zhai R.*; Liu C.*; Li D.*; Nicotinamidemononucleotide adenylyltransferase uses its NAD+ substrate-binding site tochaperone phosphorylated Tau. Elife 2020, 9, e51859.

 

9.    Lu, J.; Zhang, S.; Ma, X.; Jia, C.; Liu, Z.;Huang, C.; Liu, C.* ; Li, D.*,Structural basis of the interplay between α-synuclein and Tau in regulatingpathological amyloid aggregation. Journal of Biological Chemistry 2020, 295 (21), 7470-7480.

 

10.   Liu, Z.; Zhang, S.; Gu, J.; Tong, Y.; Li, Y.;Gui, X.; Long, H.; Wang, C.; Zhao, C.; Lu; J.; He L.; Li Y.; Liu Z.J.; Li D.*;Liu C.*, Hsp27 chaperones FUS phase separation under the modulation ofstress-induced phosphorylation. Nature Structural & Molecular Biology 2020, 27 (4), 363-372.

 

11.   Zhao, K.; Lim, Y. J.; Liu, Z.; Long, H.; Sun,Y.; Hu, J. J.; Zhao, C.; Tao, Y.; Zhang, X.; Li, D.; Li, Y. M.*; Liu, C.* ,Parkinson's disease-related phosphorylation at Tyr39 rearranges α-synucleinamyloid fibril structure revealed by cryo-EM. Proceedings of the NationalAcademy of Sciences of the United States of America 2020.

 

12.   Zhu,G. et al. Phase separation ofdisease-associated SHP2 mutants underlies MAPK hyperactivation. Cell 183, 490-502 (2020).

 

13.   Gu, J. et al. Hsp40 proteins phase separate to chaperone the assembly andmaintenance of membraneless organelles. Proceedingsof the National Academy of Sciences 117, 31123-31133 (2020).

 

14.   Sun,Y. et al. The nuclear localizationsequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEMstructure. Nature communications 11, 1-8 (2020).


2019

1.   Zhou, H.; Luo, F.; Luo, Z.; Li, D.; Liu, C.* ; Li, X.*, Programmingconventional electron microscopes for solving ultrahigh-resolution structuresof small and macro-molecules. Analytical chemistry 2019, 91(17), 10996-11003.

 

2.   Zhang, X.; Zhang, S.; Zhang, L.; Lu, J.; Zhao,C.; Luo, F.; Li, D.; Li, X.*; Liu, C.* ,Heat shock protein 104 (HSP104) chaperones soluble Tau via a mechanism distinctfrom its disaggregase activity. Journal of Biological Chemistry 2019, 294 (13), 4956-4965.

 

3.   Yu, J.; Liu, Z.; Liang, Y.; Luo, F.; Zhang,J.; Tian, C.; Motzik, A.; Zheng, M.; Kang, J.; Zhong, G.; Liu C.; Fang P.; GuoM.; Razin E.*; Wang J.*, Second messenger Ap 4 A polymerizes target proteinHINT1 to transduce signals in FcεRI-activated mast cells. Nature communications 2019, 10 (1), 1-12.

 

4.   Ma, D. F.; Xu, C. H.; Hou, W. Q.; Zhao, C.Y.; Ma, J. B.; Huang, X.; Jia, Q.; Ma, L.; Diao, J.; Liu, C.* ; Li, M.*; Lu, Y.*, Detecting Single‐Molecule Dynamics on Lipid Membraneswith Quenchers‐in‐a‐LiposomeFRET. Angewandte Chemie 2019,131 (17), 5633-5637.

 

5.   Lu, J.; Cao, Q.; Wang, C.; Zheng, J.; Luo,F.; Xie, J.; Li, Y.; Ma, X.; He, L.; Eisenberg, D. ; Nowick J. ; Jiang L.* ; LiD.*, Structure-based peptide inhibitor design of amyloid-β aggregation. Frontiersin molecular neuroscience 2019,12, 54.

 

6.   Liu,C.* ; Fang, Y.*, New insights of poly (ADP-ribosylation) inneurodegenerative diseases: A focus on protein phase separation and pathologicaggregation. Biochemical pharmacology 2019, 167, 58-63.

 

7.   Jia, C.; Ma, X.; Liu, Z.; Gu, J.; Zhang, X.; Li,D.*; Zhang, S.*, Different heat shock proteins bind α-synuclein with distinctmechanisms and synergistically prevent its amyloid aggregation. Frontiersin neuroscience 2019, 13, 1124.

 

8.   Gui, X.; Luo, F.; Li, Y.; Zhou, H.; Qin, Z.; Liu,Z.; Gu, J.; Xie, M.; Zhao, K.; Dai, B.; Shin W.; He J.; He L.; JiangL.; Zhao M.; Sun B.; Li X.; Liu C.*; Li D.*, Structural basis for reversibleamyloids of hnRNPA1 elucidates their role in stress granule assembly. Naturecommunications 2019, 10 (1), 1-12.

 

9.   Duan, Y.; Du, A.; Gu, J.; Duan, G.; Wang, C.;Gui, X.; Ma, Z.; Qian, B.; Deng, X.; Zhang, K.; Sun, L.; Tian, K.; Zhang, Y.; Jiang,H.; Liu, C.* ; Fang, Y.*, PARylationregulates stress granule dynamics, phase separation, and neurotoxicity ofdisease-related RNA-binding proteins. Cell Research 2019, 29(3), 233-247.

 

10.   Dai, B.; Sargent, C. J.; Gui, X.; Liu, C.;Zhang, F.*, Fibril Self-Assembly of Amyloid–Spider Silk Block Polypeptides. Biomacromolecules 2019, 20 (5), 2015-2023.

 

11.   Cui, M.; Wang, X.; An, B.; Zhang, C.; Gui,X.; Li, K.; Li, Y.; Ge, P.; Zhang, J.; Liu, C.; Zhang C.*, Exploiting mammalianlow-complexity domains for liquid-liquid phase separation–driven underwateradhesive coatings. Science advances 2019,5 (8), eaax3155.

 

12.   Cui, M.; Qi, Q.; Gurry, T.; Zhao, T.; An, B.;Pu, J.; Gui, X.; Cheng, A. A.; Zhang, S.; Xun; D.; Becce M.; Briatico F.; Liu C.;Lu T.; Zhong C.*, Modular genetic design of multi-domain functional amyloids:Insights into self-assembly and functional properties. Chemical science 2019, 10(14), 4004-4014.

 

2018

1.   Zhang, S.; Wang, C.; Lu, J.; Ma, X.; Liu, Z.;Li, D.; Liu, Z.; Liu, C.*  , In-cell NMR study of Tau and MARK2phosphorylated tau. International Journal of Molecular Sciences 2018, 20(1), 90.

 

2.   Luo, F.; Gui, X.; Zhou, H.; Gu, J.; Li, Y.; Liu,X.; Zhao, M.; Li, D.*; Li, X.*; Liu, C.* , Atomic structures of FUS LC domainsegments reveal bases for reversible amyloid fibril formation. Naturestructural & molecular biology 2018, 25 (4), 341-346.

 

3.   Liu, Z.; Wang, C.; Li, Y.; Zhao, C.; Li, T.; Li,D.; Zhang, S.*; Liu, C.* ,Mechanistic insights into the switch of αB-crystallin chaperone activity and self-multimerization. Journalof Biological Chemistry 2018,293 (38), 14880-14890.

 

4.   Li, Y.; Zhao, C.; Luo, F.; Liu, Z.; Gui, X.; Luo,Z.; Zhang, X.; Li, D.; Liu, C.* ;Li, X.*, Amyloid fibril structure of α-synuclein determined by cryo-electronmicroscopy. Cell research 2018, 28 (9), 897-903.

 

5.   Li, D.*; Liu,C.* , Better together: a hybrid amyloid signals necroptosis. Cell 2018, 173 (5), 1068-1070.

 

2017

1.   Liu, Z.; Zhang, S.; Li, D.; Liu, C.*  , A structural view of αB-crystallinassembly and amyloid aggregation. Protein and Peptide Letters 2017, 24(4), 315-321.

 

2.   Bu, B.; Tong, X.; Li, D.; Hu, Y.; He, W.; Zhao,C.; Hu, R.; Li, X.; Shao, Y.; Liu, C.; Zhao, Q.*; Ji, B.*; Diao, J.*,N-Terminal Acetylation Preserves α-Synuclein from Oligomerization by BlockingIntermolecular Hydrogen Bonds. ACS Chemical Neuroscience 2017, 8(10), 2145-2151.

 

3.   An, B.; Wang, X.; Cui, M.; Gui, X.; Mao, X.; Liu,Y.; Li, K.; Chu, C.; Pu, J.; Ren, S.; Wang, Y.; Zhong, G.; Lu, T. K.; Liu, C.;Zhong, C.*, Diverse Supramolecular Nanofiber Networks Assembled by FunctionalLow-Complexity Domains. ACS Nano 2017, 11 (7), 6985-6995.

 

4.   Xie, J.; Si, X.; Gu, S.; Wang, M.; Shen, J.; Li,H.; Shen, J.; Li, D.; Fang, Y.; Liu, C.* , Allosteric inhibitors of SHP2 withtherapeutic potential for cancer treatment.Journal of Medicinal Chemistry 2017, 60 (24), 10205-10219.

 

2016

1.   Wang, C.; Zhao, C.; Li, D.; Tian, Z.; Lai,Y.; Diao, J.*; Liu, C.* , Versatile structures of α-synuclein. Frontiersin molecular neuroscience 2016,9, 48.

 

2.   Yang, G.; Zhang, X.; Kochovski, Z.; Zhang,Y.; Dai, B.; Sakai, F.; Jiang, L.; Lu, Y.; Ballauff, M.; Li, X.; Liu, C.* ;Chen, G.*; Jiang, M., Precise and Reversible Protein-Microtubule-Like Structurewith Helicity Driven by Dual Supramolecular Interactions. Journal of the AmericanChemical Society 2016, 138 (6), 1932-1937..

 

2015

1.   Dai, B.; Li, D.; Xi, W.; Luo, F.; Zhang, X.; Zou,M.; Cao, M.; Hu, J.; Wang, W.; Wei, G.*; Zhang, Y.*; Liu, C.* , Tunableassembly of amyloid-forming peptides into nanosheets as a retrovirus carrier. Proceedingsof the National Academy of Sciences 2015, 112 (10), 2996.

 

2014

1.   Hochberg, G. K. A.; Ecroyd, H.; Liu, C.; Cox,D.; Cascio, D.; Sawaya, M. R.; Collier, M. P.; Stroud, J.; Carver, J. A.; Baldwin,A. J.; Robinson, C. V.; Eisenberg, D.; Benesch, J. L. P.*;Laganowsky, A.*, The structured core domain ofαB-crystallin can prevent amyloid fibrillation and associated toxicity. Proceedingsof the National Academy of Sciences 2014, 111 (16), E1562.

 

2.   Li, D.; Jones, E. M.; Sawaya, M. R.; Furukawa,H.; Luo, F.; Ivanova, M.; Sievers, S. A.; Wang, W.; Yaghi, O. M.; Liu, C.;Eisenberg, D.*, Structure-Based Design of Functional Amyloid Materials. Journalof the American Chemical Society 2014, 136 (52), 18044-18051.

 

3.   Li, D.; Furukawa, H.; Deng, H.; Liu, C.; Yaghi,O. M.*; Eisenberg, D.*, Designed amyloid fibers as materials for selectivecarbon dioxide capture. Proceedings of the National Academy of Sciences 2014, 111 (1), 191.

 

4.   Gu, L.; Liu, C.; Stroud, J. C.; Ngo, S.; Jiang,L.; Guo, Z.*, Antiparallel triple-strand architecture for prefibrillar Aβ42oligomers. Journal of Biological Chemistry 2014, 289 (39), 27300-27313.

 

2013

1.   Jiang, L.; Liu, C.; Leibly, D.; Landau, M.; Zhao,M.; Hughes, M. P.; Eisenberg, D.*, Structure-based discovery of fiber-bindingcompounds that reduce the cytotoxicity of amyloid beta. Elife 2013, 2,e00857.

 

2.   Gu, L.; Liu, C.; Guo, Z.*, Structuralinsights into Aβ42 oligomers using site-directed spin labeling. Journal of Biological Chemistry 2013,288 (26), 18673-18683.

 

2012

1.   Stroud, J. C.; Liu, C.; Teng, P.; Eisenberg,D.*, Toxic fibrillar oligomers of amyloid-β have cross-β structure. Proceedings of the National Academy of Sciences 2012, 109 (20), 7717-7722.

 

2.   Li, D.; Fu, T.; Nan, J.; Liu, C.; Li, L.; Su,X.*, Structural basis for the autoinhibition of the C-terminal kinase domain ofhuman RSK1. Acta Crystallographica Section D: Biological Crystallography 2012, 68 (6), 680-685.

 

3.   Liu, C.; Zhao, M.; Jiang, L.; Cheng, P.; Park,J.; Sawaya, M. R.; Pensalfini, A.; Gou, D.; Berk, A. J.; Glabe, C. G.; Nowick,J.*; Eisenberg, D.*, Out-of-register β-sheets suggest a pathway to toxicamyloid aggregates. Proceedings of the National Academy of Sciences 2012, 109(51), 20913.

 

4.   Laganowsky, A.; Liu, C.; Sawaya, M. R.; Whitelegge,J. P.; Park, J.; Zhao, M.; Pensalfini, A.; Soriaga, A. B.; Landau, M.; Teng, P.K.; Cascio, D.; Glabe, C.; Eisenberg, D.*, Atomic View of a Toxic Amyloid SmallOligomer. Science 2012, 335 (6073), 1228.

 

5.   Cheng, P.-N.; Liu, C.; Zhao, M.; Eisenberg,D.*; Nowick, J. S.*, Amyloid β-sheet mimics thatantagonize protein aggregation and reduce amyloid toxicity. Nature chemistry 2012, 4(11), 927-933.

 

2011

1.   Liu, C.; Sawaya, M. R.; Eisenberg, D.*, β2-microglobulin forms three-dimensional domain-swapped amyloid fibrils withdisulfide linkages. Nature structural & molecular biology 2011, 18(1), 49.

 

2.   Zheng, J.; Liu, C.; Sawaya, M. R.; Vadla, B.;Khan, S.; Woods, R. J.; Eisenberg, D.; Goux, W. J.; Nowick, J. S.*, Macrocyclicβ-sheet peptides that inhibit the aggregation of a tau-protein-derivedhexapeptide. Journal of the American Chemical Society 2011, 133(9), 3144-3157.

 

3.   Liu, C.; Sawaya, M. R.; Cheng, P.; Zheng, J.;Nowick, J. S.; Eisenberg, D.*, Characteristics of amyloid-related oligomersrevealed by crystal structures of macrocyclic β-sheet mimics. Journalof the American Chemical Society 2011, 133 (17), 6736-6744.

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