1997-2002： 安徽理工大学医学院 学士
2002-2007： 中国科学院上海生命科学研究院健康科学研究所 博士
2008-2014： 德国癌症研究中心 博士后
2015-至今： 中国科学院生物与化学交叉研究中心， 研究员

血管网络不仅向组织提供各种营养物质与氧气，同时通过分泌多种细胞因子形成特殊的血管微环境（vascular niche）用以调控周围细胞的功能。 血管功能的异常激活或衰退与许多疾病的进展紧密相关。如肿瘤的发展过程中，血管新生机制被过度激活，从而形成大量畸形的血管。这些血管不仅促进肿瘤的生长，同时其紊乱的血管结构使得治疗药物不能有效进入肿瘤内部。 在衰老过程中，血管内皮细胞功能的衰退，不仅引起各种心血管疾病，同时也抑制相应组织内干细胞自我更新和修复并导致器官的功能减退。

本实验室主要研究血管在衰老和疾病过程中的功能改变。将综合应用下一代测序技术，高分辨率显微成像技术，并制备新的动物模型用以研究以下问题：
1. 血管新生过程中，不同血管内皮细胞群体的特性。并筛选新一代特异性的抑制肿瘤血管新生的药物。
2. 神经退行性疾病过程中，血管功能的改变，并探索基于改善血管内皮细胞功能的治疗方法。

1. Zhuang, Z.H., Sun, L., Kong, L., Hu, J., Yu, M.C., Reinach, P., Zang, J.W., and Ge, B.X., (2006). Drosophila TAB2 is required for the immune activation of JNK and NF-kappaB. Cellular Signalling 18, 964-970.
2. Hu, J., Chen, T., Zhuang, Z.H., Kong, L., Yu, M.C., Liu, Y., Zang, J.W., and Ge, B.X., (2007). Feedback control of MKP-1 expression by p38. Cellular Signalling 19, 393-400.
3. Sun, L., Yu, M.C., Kong, L., Zhuang, Z.H., Hu, J., and Ge, B.X., (2008). Molecular identification and functional characterization of a Drosophila dual-specificity phosphatase DMKP-4 which is involved in PGN-induced activation of the JNK pathway. Cellular Signalling 20, 1329-1337.
4. Yu, M.C., Su, L.L., Zou, L., Liu, Y., Wu, N., Kong, L., Zhuang, Z.H., Sun, L., Liu, H.P., Hu, J., Ge, B.X., et al. (2008). An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells. Nature Immunology 9, 898-907.
5. Norrmen, C., Ivanov, K.I., Cheng, J., Zangger, N., Delorenzi, M., Jaquet, M., Miura, N., Puolakkainen, P., Horsley, V., Hu, J., et al. (2009). FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1. Journal of Cell Biology 185, 439-457.
6. Kong, L., Sun, L., Zhang, H., Liu, Q., Liu, Y., Qin, L., Shi, G., Hu, J., Xu, A., Sun, Y.P., Ge, B.X., et al. (2009). An essential role for RIG-I in toll-like receptor-stimulated phagocytosis. Cell Host & Microbe 6, 150-161.
7. Licht, A. H.*, Nübel, T.*, Feldner, A., Jurisch-Yaksi, N., Marcello, M., Demicheva, E., Hu, J., Schorpp-Kistner, M., et al. (2010). Junb regulates arterial contraction capacity, cellular contractility, and motility via its target Myl9 in mice. Journal of Clinical Investigation 120, 2307-2318.
8. Felcht, M., Luck, R., Schering, A., Seidel, P., Srivastava, K., Hu, J., et al. (2012). Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling. Journal of Clinical Investigation, 122(6), 1991–2005. doi:10.1172/JCI58832
9. Ziegler, T., Horstkotte, J., Schwab, C., Pfetsch, V., Weinmann, K., Dietzel, S., Rohwedder, I., Hinkel, R. Gross, L., Lee, S., Hu, J., Franz. W.M., et al., (2013) Angiopoietin-2 mediates microvascular and hemodynamic alterations in sepsis. Journal of Clinical Investigation 123,3436-3445.
10. Korn C.*, Scholz B.*, Hu, J., Srivastava K., Wojtarowicz J., Arnsperger T., Adams R., Boutros M., Augustin H.G., Augustin I. (2014) Endothelial cell-derived non-canonical Wnt ligands control vascular prunning in angiogenesis. Development 141, 1757-1766
111. Runge, A., Hu, J., Wieland, M., Bergeest, J.P., Mogler, C., Komljenovic, D., Augustin, H.G., et al. (2014) An inducible hepatocellular carcinoma model for preclinical evaluation of antiangiogenic therapy in adult mice. Cancer Research 74, 4157-4169
12. Hu, J.*, Srivastava, K.*, Wieland, M., Rung, A., Mogler, C., Besemfelder E. Augustin, H.G., et al. (2014) Endothelial cell-derived Angiopoietin-2 controls liver regeneration as a spatiotemporal rheostat. (*co-first authors) Science 343, 416-419
13. Srivastava, K.*, Hu, J.*, Korn, C., Augustin, H.G., et al. (2014) Postsurgical adjuvant tumor therapy by combining anti-Angiopoietin-2 and metronomic chemotherapy effectively limits metastatic progression. (*co-first authors) Cancer Cell 26, 880-895