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团队成员

刘建平

电话:021-68582560
邮箱:jpliu@sioc.ac.cn

简介

2004/09-2011/07 中国科学技术大学分子生物学与细胞生物学 博士学位
2011/08-2012/08 香港科技大学大学医学院 博士后
2012/09-2016/08 中国科学院上海有机化学研究所 助理研究员
2016/09-至今 中国科学院上海有机化学研究所 副研究员

研究方向
综合利用X射线晶体衍射、溶液核磁共振、冷冻电镜以及分子生物学等手段研究蛋白质结构与功能,阐释蛋白质之间以及蛋白质与小分子化合物之间的相互作用机制。特别关注RIPK1激酶在TNFa通路中的信号复合物的调控机制。
代表论文

Journal papers
[1] Jianping Liu, Lifeng Pan*, Structural bases of the assembly, recognition and disassembly of linear ubiquitin chain, Biochim Biophys Acta Mol Cell Res., 2018 Jul 5;1865(10):1410-1422.
[2] Jianping Liu, Yingli Wang, Yukang Gong, Tao Fu, Shichen Hu, Zixuan Zhou, Lifeng Pan*, Structural Insights into SHARPIN-Mediated Activation of HOIP for the Linear Ubiquitin Chain Assembly, Cell Reports, 2017, 21(1):27-36.
[3] Jianping Liu, Jiahai Zhang, Qingguo Gong, Peng Xiong, Hongda Huang, Bo Wu, Guowei Lu, Jihui Wu* and Yunyu Shi, Solution structure of tandem SH2 Domains from Spt6 protein and their binding to the phosphorylated RNA polymerase II C-terminal domain, 2011, 286(33): 29218-29226
[4] Daichao Xu#, Jianping Liu#,Tao Fu, Bing Shan, Lihui Qian, Lifeng Pan*, and Junying Yuan*, USP25 Regulates Wnt Signaling by Controlling the Stability of Tankyrases, Genes & Development, 2017, 31: 1024-1035. (# Co-first)
[5] Ran Wei#, Lily Wen Xu#, Jianping Liu, Yanxia Li, Pei Zhang, Bing Shan, Xiaojuan Lu,Lihui Qian, Zheming Wu, Kangyun Dong, Hong Zhu, Lifeng Pan, Junying Yuan*, and Heling Pan*, SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination, Genes & Development, 2017,31:1-15。(# Co-first)
[6] Xiaolong Xu, Jianping Liu, Yingli Wang, Yaru Wang, Xingyu Gong, Lifeng Pan*, Mechanistic insights into the interactions of Ras subfamily GTPases with the SPR domain of autism-associated SHANK3, Chinese Journal of Chemistry, 2020, doi:10.1002/cjoc.202000278
[7] Tao Fu, Jianping Liu, Yingli Wang, Xingqiao Xie, Sichen Hu, Lifeng Pan*, Mechanistic insights into the interactions of NAP1 with the SKICH domains of NDP52 and TAX1BP1 PNAS. 2018, 115, E11651-E11660.


Book chapter
[1] Jianping Liu, Ying Li, Lifeng Pan, Structural Basis of Autophagy Regulatory Proteins, Advances in Experimental Medicine and Biology, 2019, 1206:287-326. (invited book chapter review).

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