中国科学院生物与化学交叉研究中心

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团队成员

敬洪阳

邮箱:jinghongyangJHY@126.com

简介

2021年10月至今 中国科学院上海有机化学研究所化学和生物交叉中心

2020年02月至2020年09月 研究助理,美国凯斯西储大学

2018年03月至2020年02月 访问学者,美国凯斯西储大学

2016年09月至2021年07月 博士,南昌大学


研究方向

神经炎症与生物钟在神经退行性疾病中的研究

代表论文

Jing, H.*, P. Chen*, T. Hui, Z. Yu, J. Zhou, E. Fei, S. Wang, D. Ren, X. Lai and B. Li (2021). "Synapse-specific Lrp4 mRNA enrichment requires Lrp4/MuSK signaling, muscle activity and Wnt non-canonical pathway." Cell Biosci 11(1): 105.

Xing, G., H. Jing, Z. Yu, P. Chen, H. Wang, W. C. Xiong and L. Mei (2021). "Membraneless condensates by Rapsn phase separation as a platform for neuromuscular junction formation." Neuron.

Yu, Z.*, M. Zhang*, H. Jing*, P. Chen*, R. Cao, J. Pan, B. Luo, Y. Yu, B. M. Quarles, W. Xiong, M. H. Rivner and L. Mei (2021). "Characterization of LRP4/Agrin Antibodies From a Patient with Myasthenia Gravis." Neurology. 

Chen, P.*, H. Jing*, M. Xiong, Q. Zhang, D. Lin, D. Ren, S. Wang, D. Yin, Y. Chen, T. Zhou, B. Li, E. Fei and B. X. Pan (2021). "Spine impairment in mice high-expressing neuregulin 1 due to LIMK1 activation." Cell Death Dis 12(4): 403.

Hui, T., H. Jing and X. Lai (2021). "Neuromuscular junction-specific genes screening by deep RNA-seq analysis." Cell Biosci 11(1): 81.

Hui, T., H. Jing, T. Zhou, P. Chen, Z. Liu, X. Dong, M. Yan, D. Ren, S. Zou, S. Wang, E. Fei, D. Hong and X. Lai (2021). "Increasing LRP4 diminishes neuromuscular deficits in a mouse model of Duchenne muscular dystrophy." Hum Mol Genet.

Hui, T. K., X. S. Lai, X. Dong, H. Jing, Z. Liu, E. Fei, W. B. Chen, S. Wang, D. Ren, S. Zou, H. T. Wu and B. X. Pan (2021). "Ablation of Lrp4 in Schwann Cells Promotes Peripheral Nerve Regeneration in Mice." Biology (Basel) 10(6).

Gao, N., K. Zhao, Y. Cao, X. Ren, H. Jing, G. Xing, W. C. Xiong and L. Mei (2020). "A Role of Lamin A/C in Preventing Neuromuscular Junction Decline in Mice." J Neurosci 40(38): 7203-7215.

Zhang, H., W. Chen, Z. Tan, L. Zhang, Z. Dong, W. Cui, K. Zhao, H. Wang, H. Jing, R. Cao, C. Kim, J. G. Safar, W. C. Xiong and L. Mei (2020). "A Role of Low-Density Lipoprotein Receptor-Related Protein 4 (LRP4) in Astrocytic Abeta Clearance." J Neurosci 40(28): 5347-5361.

Zhang, L., H. Jing, H. Li, W. Chen, B. Luo, H. Zhang, Z. Dong, L. Li, H. Su, W. C. Xiong and L. Mei (2020). "Neddylation is critical to cortical development by regulating Wnt/beta-catenin signaling." Proc Natl Acad Sci U S A.

Yan, M., A. Guo, P. Chen, H. Jing, D. Ren, Y. Zhong, Y. Wu, E. Fei, X. Lai, S. Zou and S. Wang (2020). "LRP4 LDLalpha repeats of astrocyte enhance dendrite arborization of the neuron." Mol Brain 13(1): 166.

Yu, Z., M. Zhang, B. Luo, H. Jing, Y. Yu, S. Wang and S. Luo (2020). "Lrp4 in hippocampal astrocytes serves as a negative feedback factor in seizures." Cell & Bioscience 10(1): 1-14.

Xing, G.*, H. Jing*, L. Zhang, Y. Cao, L. Li, K. Zhao, Z. Dong, W. Chen, H. Wang, R. Cao, W. C. Xiong and L. Mei (2019). "A mechanism in agrin signaling revealed by a prevalent Rapsyn mutation in congenital myasthenic syndrome." Elife 8.

Yan, M., Z. Liu, E. Fei, W. Chen, X. Lai, B. Luo, P. Chen, H. Jing, J. X. Pan, M. H. Rivner, W. C. Xiong and L. Mei (2018). "Induction of Anti-agrin Antibodies Causes Myasthenia Gravis in Mice." Neuroscience 373: 113-121.

Zhao, K., C. Shen, L. Li, H. Wu, G. Xing, Z. Dong, H. Jing, W. Chen, H. Zhang, Z. Tan, J. Pan, L. Xiong, H. Wang, W. Cui, X. D. Sun, S. Li, X. Huang, W. C. Xiong and L. Mei (2018). "Sarcoglycan Alpha Mitigates Neuromuscular Junction Decline in Aged Mice by Stabilizing LRP4." J Neurosci 38(41): 8860-8873.

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