2013 年11月至今　副研究员　中国科学院上海有机化学研究所化学和生物交叉中心

2011年10月至2013年8月　博士后　美国Scripps研究所

2010年9月至2011年9月 博士后 德国马普精神病研究所

2007年9月至2010年8月　博士　慕尼黑大学

1. Quantitative analysis of phosphoproteome in necroptosis reveals a role of TRIM28 phosphorylation in promoting necroptosis-induced cytokine production. Zu R, Yu Z, Zhao J, Lu X, Liang W, Sun L, Si C, Zhu K, Zhang T, Li G, Zhang M, Zhang Y, Liu N, Yuan J*, Shan B*. Cell Death Dis. 2021 Oct 23;12(11):994. doi: 10.1038/s41419-021-04290-7. PMID: 34689152

2. NEK1-mediated retromer trafficking promotes blood-brain barrier integrity by regulating glucose metabolism and RIPK1 activation. Wang H, Qi W, Zou C, Xie Z, Zhang M, Naito MG, Mifflin L, Liu Z, Najafov A, Pan H, Shan B, Li Y, Zhu ZJ, Yuan J*. Nat Commun. 2021 Aug 10;12(1):4826. doi: 10.1038/s41467-021-25157-7. PMID: 34376696

3. Discovery of a cooperative mode of inhibiting RIPK1 kinase. Meng H, Wu G, Zhao X, Wang A, Li D, Tong Y, Jin T, Cao Y, Shan B, Hu S, Li Y, Pan L, Tian X, Wu P, Peng C, Yuan J, Li G*, Tan L*, Wang Z*, Li Y*. Cell Discov. 2021 Jun 1;7(1):41. doi: 10.1038/s41421-021-00278-x. PMID: 34075030

4. Caspase inhibition prolongs inflammation by promoting a signaling complex with activated RIPK1.

5. Huang X, Tan S, Li Y, Cao S, Li X, Pan H, Shan B, Qian L, Yuan J*. J Cell Biol. 2021 Jun 7;220(6):e202007127. doi: 10.1083/jcb.202007127. PMID: 33914027

6. Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners. Li X, Zhang M, Huang X, Liang W, Li G, Lu X, Li Y, Pan H, Shi L, Zhu H, Qian L, Shan B*, Yuan J*. Nat Commun. 2020 Dec 11;11(1):6364. doi: 10.1038/s41467-020-19935-y. PMID: 33311474

7. Reduction of mNAT1/hNAT2 Contributes to Cerebral Endothelial Necroptosis and Aβ Accumulation in Alzheimer's Disease.

8. Zou C, Mifflin L, Hu Z, Zhang T, Shan B, Wang H, Xing X, Zhu H, Adiconis X, Levin JZ, Li F, Liu CF, Liu JS, Yuan J*. Cell Rep. 2020 Dec 8;33(10):108447. doi: 10.1016/j.celrep.2020.108447. PMID: 33296651

9. Modulating TRADD to restore cellular homeostasis and inhibit apoptosis. Xu D, Zhao H, Jin M, Zhu H, Shan B, Geng J, Dziedzic SA, Amin P, Mifflin L, Naito MG, Najafov A, Xing J, Yan L, Liu J, Qin Y, Hu X, Wang H, Zhang M, Manuel VJ, Tan L, He Z, Sun ZJ, Lee VMY, Wagner G, Yuan J*. Nature. 2020 Nov;587(7832):133-138. doi: 10.1038/s41586-020-2757-z. Epub 2020 Sep 23. PMID: 32968279

10. Chaperone-mediated autophagy is involved in the execution of ferroptosis. Wu Z, Geng Y, Lu X, Shi Y, Wu G, Zhang M, Shan B, Pan H, Yuan J. Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2996-3005. doi: 10.1073/pnas.1819728116. Epub 2019 Feb 4. PMID: 30718432

11. TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging. Xu D, Jin T, Zhu H, Chen H, Ofengeim D, Zou C, Mifflin L, Pan L, Amin P, Li W, Shan B, Naito MG, Meng H, Li Y, Pan H, Aron L, Adiconis X, Levin JZ, Yankner BA, Yuan J*. Cell. 2018 Sep 6;174(6):1477-1491.e19. doi: 10.1016/j.cell.2018.07.041. Epub 2018 Aug 23. PMID: 30146158

12. Necroptosis in development and diseases. Shan B^#, Pan H^#, Najafov A, Yuan J*. Genes Dev. 2018 Mar 1;32(5-6):327-340. doi: 10.1101/gad.312561.118. PMID: 29593066