2025
(1-47)
1. Sadeem Ahmad, Zou Tao, Hwang Jihee, Zhao Linlin, Wang Xi, Davydenko Anton, Buchumenski Ilana, Zhuang Patrick, Fishbein Alyssa R., Capcha-Rodriguez Diego, Orgel Aaron, Levanon Erez Y., Myong Sua, Chou James, Meyerson Matthew & Hur Sun. PACT prevents aberrant activation of PKR by endogenous dsRNA without sequestration. Nature Communications 16 (2025).
2. Jiahui Chen, Zhang Yimin, Chen Nanhao, Ge Jingpeng & Yu Jie. Transport and inhibition mechanisms of human creatine transporter. Cell Discovery 11 (2025).
3. Pengda Chen, Lin Lianghua, Lin Xinyong, Liao Kunyu, Qiang Jiali, Wang Zhizhang, Wu Jianfeng, Li Yang, Yang Liang, Yao Nan, Song Huilin, Hong Yazhen, Liu Wen-Hsien, Zhang Yaoyang, Chang Xing, Du Dan & Xiao Changchun. A Csde1-Strap complex regulates plasma cell differentiation by coupling mRNA translation and decay. Nature Communications 16 (2025).
4. Zhixiang Chen, Dhruv Harshil, Zhang Xuqing, Rej Rohan Kalyan, Bai Longchuan, McEachern Donna, Kirchhoff Paul, Nagilla Rakesh, Jolivette Larry J., Rice Cory T., Orth Peter, Strickland Corey O., Priestley E. Scott, Mohammad Helai P., Wang Meilin, Wen Bo, Sun Duxin, Sui Zhihua & Wang Shaomeng. Development of PVTX-405 as a potent and highly selective molecular glue degrader of IKZF2 for cancer immunotherapy. Nature Communications 16 (2025).
5. Jing Gao, Liu Yang, Si Chenfang, Guo Rui, Hou Shouqiao, Liu Xiaosong, Long Houfang, Liu Di, Xu Daichao, Zhang Zai-Rong, Liu Cong, Shan Bing, Turck Christoph W., He Kaiwen & Zhang Yaoyang. Aspirin inhibits proteasomal degradation and promotes α-synuclein aggregate clearance through K63 ubiquitination. Nature Communications 16 (2025).
6. Yang Gao, Luo Mingdu, Wang Hongmiao, Zhou Zhiwei, Yin Yandong, Wang Ruohong, Xing Beizi, Yang Xiaohua, Cai Yuping & Zhu Zheng-Jiang. Charting unknown metabolic reactions by mass spectrometry-resolved stable-isotope tracing metabolomics. Nature Communications 16 (2025).
7. Xueqi Gong, Gao Haitong, Wang Wenyuan & Xu Tonghui. Intramuscular Injection of rAAV2-retro for Low Motor Neuron Transduction: Evaluating Five Promoters. International Journal of Medical Sciences 22, 775-789 (2025).
8. Yaoyao Han, Han Qian, Tang Qianqian, Zhang Yixiao & Liu Kai. Molecular basis for the stepwise and faithful maturation of the 20S proteasome. Science Advances 11 (2025).
9. Yuliang Han, Li Juan, Xia Wencheng, Li Qintong, Sun Zihan, Zeng Wen, Hu Yingxin, Luk Kelvin C., Liu Cong, Xiang ShengQi & He Zhuohao. Fibril fuzzy coat is important for alpha-synuclein pathological transmission activity. Neuron 113, 1723-1740.e1727 (2025).
10. Kai He, Dong Xue, Yang Tianjing, Li Ziqi, Liu Yuming, He Jing, Wu Meng, Wei-Zhang Selena, Kaysar Parhat, Cui Bohao, Yao Xueming, Zhang Li, Zhou Wei, Xu Heping, Wei Jun, Liu Qiang, Hu Junhao, Wang Xiaohong & Yan Hua. Smoking aggravates neovascular age-related macular degeneration via Sema4D-PlexinB1 axis-mediated activation of pericytes. Nature Communications 16 (2025).
11. Tingting Huang, Xie Wanqing, Guo Yunlu, Li Yan, Yin Jiemin, Jin Xia, Ma Yezhi, Zhang Yueman, Huang Dan, Chen Caiyang, Wang Xin, Zhu Ziyu, Gan Yu, Liesz Arthur, Yu Weifeng, Yuan Junying & Li Peiying. St3gal5-mediated sialylation of glyco-CD177 on neutrophils restricts neuroinflammation following CNS injury. Proceedings of the National Academy of Sciences of the United States of America 122 (2025).
12. Xin Huang, Li Fangxia, Liu Lin, Li Yanxia, Zhang Mengmeng, Ma Guoming, Gao Ying, Shan Bing, Liang Xiaozhen, Yuan Junying & Pan Heling. PARP12-mediated mono-ADP-ribosylation as a checkpoint for necroptosis and apoptosis. Proceedings of the National Academy of Sciences of the United States of America 122, e2426660122-e2426660122 (2025).
13. Yi Lei, Hu Jiandong, Zhao Jiyun, Liu Qiangyun, Zhang Selena Wei, Wu Fangfang, Liu Yuming, Ren Honglei, Qin Xiaoyang, Wu Xudong, Gao Fei, Hu Junhao, Ouyang Kunfu, Liu Qiang, Zheng Xiangjian, Shi Lei & Wang Xiaohong. Deubiquitinase USP9X controls Wnt signaling for CNS vascular formation and barrier maintenance. Developmental Cell 60 (2025).
14. Dan Li, Liu Kaien, Li Danni, Brunger Axel, Li Cong, Burre Jacqueline & Diao Jiajie. alpha-Synuclein condensation in synaptic vesicle function and synucleinopathies. Trends in cell biology (2025).
15. Xiang Li, Bi Lulu, Zhang Shenqing, Xu Qianhui, Xia Wencheng, Tao Youqi, Wu Shaojuan, Li Yanan, Le Weidong, Kang Wenyan, Li Dan, Sun Bo & Liu Cong. Single-Molecule Insight Into α-Synuclein Fibril Structure and Mechanics Modulated by Chemical Compounds. Advanced Science 12 (2025).
16. Di Liu, Huo Xin-Yu, Zhang Xiaoli & Zhang Zai-Rong. The E3 ubiquitin ligase RNF126 facilitates quality control of unimported mitochondrial membrane proteins. Journal of Biological Chemistry 301 (2025).
17. Hongqin Liu, Chen Xi, Wang Hanlin, Zhuang Guanglei, Zhu Zheng-Jiang & Zhuang Min. ZBTB17/MIZ1 promotes peroxisome biogenesis by transcriptional regulation of PEX13. Journal of Cell Biology 224 (2025).
18. Zijiao Liu, Zhang Jun, Jiang Fei, Liu Cong, Shao Yaping & Le Weidong. Biological Effects of Dietary Restriction on Alzheimer's Disease: Experimental and Clinical Investigations. Cns Neuroscience & Therapeutics 31 (2025).
19. Mengxun Luo, Zhou Jia, Sun Cailu, Chen Wanjia, Fu Chaoying, Si Chenfang, Zhang Yaoyang, Geng Yang & Chen Yelin. APP beta-CTF triggers cell-autonomous synaptic toxicity independent of Abeta. eLife 13 (2025).
20. Dingbang Ma, Le Jasmine Quynh, Dai Xihuimin, Diaz Madelen M., Abruzzi Katharine C. & Rosbash Michael. Transcriptomic DN3 clock neuron subtypes regulate Drosophila sleep. Science Advances 11 (2025).
21. Yingjie Ning, Xu Ruisheng, Yu Jie & Ge Jingpeng. Structural basis for catalytic mechanism of human phosphatidylserine synthase 1. Cell Discovery 11 (2025).
22. Ziyu Sun, Ye Jianyu, Sun Weimin, Jiang Libo, Shan Bing, Zhang Mengmeng, Xu Jingyi, Li Wanjin, Liu Jianping, Jing Hongyang, Zhang Tian, Hou Meiling, Xie Cen, Wu Rongling, Pan Heling & Yuan Junying. Cooperation of TRADD- and RIPK1-dependent cell death pathways in maintaining intestinal homeostasis. Nature Communications 16 (2025).
23. Xuelin Tang, Chen Yan, Ren Yongfei, Yang Wanli, Yu Wendi, Zhou Yu, Guo Jingyan, Hu Jiali, Chen Xi, Gu Yuqi, Wang Chuyi, Dong Yi, Yang Hong, Sato Christine, He Ji, Fan Dongsheng, You Linya, Zinman Lorne, Rogaeva Ekaterina, Chen Yelin & Zhang Ming. Deep learning analyses of splicing variants identify the link of PCP4 with amyotrophic lateral sclerosis. Brain (2025).
24. Yubin Tang, Han Yaoyao, Guo Zhenpeng, Li Ying, Gong Xinyu, Zhang Yuchao, Liu Haobo, Zhou Xindi, Xu Daichao, Zhang Yixiao & Pan Lifeng. Mechanistic insights into the GEF activity of the human MON1A/CCZ1/C18orf8 complex. Protein & Cell (2025).
25. Teng Teng, Huang Fang, Xu Ming, Li Xuemei, Zhang Lige, Yin Bangmin, Cai Yuping, Chen Fei, Zhang Luman, Zhang Jushuang, Geng Aoyi, Chen Chengzhi, Yu Xiaofei, Sui Jing, Zhu Zheng-Jiang, Guo Kai, Zhang Chenhong & Zhou Xinyu. Microbiota alterations leading to amino acid deficiency contribute to depression in children and adolescents. Microbiome 13 (2025).
26. Huilan Wang, Wang Qing, Xu Haoxiang, Wu Yuanzheng, Cheung Siulam, Xu Qianhui, Pan Chengfang, Cao Jingyu, Cao Zhiyuan, Yang Ruonan, Ding Yu, Fei Yiyan, Chen Yongfeng, Wang Jian, Liu Cong & Lu Boxun. MEK1/2 inhibitors suppress pathological α-synuclein and neurotoxicity in cell models and a humanized mouse model of Parkinson's disease. Science Translational Medicine 17 (2025).
27. Peng Wang, Ouyang Hui, Bi Guofang, Liang Fengting, Hu Shuang, Wu Chenghua, Jiang Xiaowen, Zhou Wenhong, Li Dan, Zhang Shuaishuai, Yang Xiao, Zhao Mingliang, Fang Jian-Hong, Wang Haitao, Jia Wei, Zhu Zheng-jiang & Bi Huichang. Schisandrol B alleviates depression-like behavior in mice by regulating bile acid homeostasis in the brain-liver-gut axis via the pregnane X receptor. Phytomedicine 137 (2025).
28. Qianwen Wang, Liu Zhengtao, Wang Youjia, Liu Yuan, Chen Ying, Zhang Shengnan, Zeng Wen, Li Dan, Yang Fan, He Zhuohao, Xiao Weidi, Liu Cong & Wang Chu. Quantitative chemoproteomics reveals dopamine's protective modification of Tau. Nature Chemical Biology (2025).
29. Kai-Min Wu, Xu Qian-Hui, Liu Yi-Qi, Feng Yi-Wei, Han Si-Da, Zhang Ya-Ru, Chen Shi-Dong, Guo Yu, Wu Bang-Sheng, Ma Ling-Zhi, Zhang Yi, Chen Yi-Lin, Yang Liu, Yang Zhao-Fei, Xiao Yu-Jie, Wang Ting-Ting, Zhao Jue, Chen Shu-Fen, Cui Mei, Lu Bo-Xun, Le Wei-Dong, Shu You-Sheng, Ye Keqiang, Li Jia-Yi, Li Wen-Sheng, Wang Jian, Liu Cong, Yuan Peng & Yu Jin-Tai. Neuronal FAM171A2 mediates alpha-synuclein fibril uptake and drives Parkinson's disease. Science (New York, N.Y.) 387, 892-900 (2025).
30. Wencheng Xia, Xu Zhongxin, Dong Hui, Zhang Shengnan, He Changdong, Li Dan, Sun Bo, Dai Bin, Dong Suwei & Liu Cong. Design and Structural Elucidation of Glycopeptide Fibrils: Emulating Glycosaminoglycan Functions for Biomedical Applications. Journal of the American Chemical Society 147, 20132-20143 (2025).
31. Zhangdan Xie, Lin Moubin, Xing Beizi, Wang Hongmiao, Zhang Haosong, Cai Zimu, Mei Xinyu & Zhu Zheng-Jiang. Citrulline regulates macrophage metabolism and inflammation to counter aging in mice. Science Advances 11 (2025).
32. Beizi Xing, Wang Ruohong, Kou Tianzhang, Liu Wenbin & Zhu Zheng-Jiang. Unraveling Tissue-Specific Fatty Acid Biosynthesis and Inter-Tissue Crosstalk in Mice through Stable-Isotope Tracing Metabolomics. Advanced Science (2025).
33. Yongyi Xu, Li Danni, Zhang Yiling, Zhao Qinyue, Sun Bo, Liu Cong, Li Dan & Dai Bin. β-Lactoglobulin Forms a Conserved Fibril Core That Assembles into Diverse Fibril Polymorphs. Nano Letters 25, 3653-3661 (2025).
34. Hao Yang, Wang Tongyao, Qian Chenglang, Wang Huijing, Yu Dong, Shi Meifang, Fu Mengwei, Liu Xueguang, Pan Miaomiao, Rong Xingyu, Xiao Zhenming, Chen Xiejiu, Yeerken Anaguli, Wu Yonglin, Zheng Yufan, Yang Hui, Zhang Ming, Liu Tao, Qiao Peng, Qu Yifan, Lin Yong, Huang Yiqin, Jin Jianliang, Liu Nan, Wen Yumei, Sun Ning & Zhao Chao. Gut microbial-derived phenylacetylglutamine accelerates host cellular senescence. Nature Aging 5 (2025).
35. Xiaohua Yang, Kou Tianzhang, Wang Hongmiao, Zhu Ji, Zhu Zheng-Jiang & Cai Yuping. S-adenosylmethionine metabolism shapes CD8+ T cell functions in colorectal cancer. Cancer & metabolism 13 (2025).
36. Cheng Yao, Wei Ruwei, Luo Xiao, Zhou Jie, Zhang Xiaodong, Lu Xicun, Dong Yan, Chu Ruofan, Sun Yuxin, Wang Yu, Xia Wencheng, Qu Dahui, Liu Cong, Ren Jun, Ge Guangbo, Chen Jinquan, Qian Xuhong & Yang Youjun. A stable and biocompatible shortwave infrared nanoribbon for dual-channel in vivo imaging. Nature Communications 16 (2025).
37. Jiaqi Zhang, Hu Jiaojiao, Liu Ruogu, Zhou Tian, Luo Xuewei, Liang Peigang, Xie Zaichao, Zhao Qinyue, Chen Yan, Du Dan, Liu Cong, Zheng Yiming, Li Dan & Wang Bo. YAP maintains the dynamics of TDP-43 condensates and antagonizes TDP-43 pathological aggregates. Nature Cell Biology (2025).
38. Mengjun Zhang, Gu Zhuang, Sun Yingtian, Dong Yichen, Chen Junlin, Shu Li, Ma Suibin, Guo Jierui, Liang Yuhang, Qu Qingming, Fang Ning, Zhong Chuan-Qi, Ge Yifan, Chen Zhongwen, Huang Shaohui, Zhang Xin & Wang Bo. Phosphorylation-dependent charge blocks regulate the relaxation of nuclear speckle networks. Molecular cell 85 (2025).
39. Na Zhang & Xu Daichao. Controlling pyroptosis through post-translational modifications of gasdermin D. Developmental Cell 60, 994-1007 (2025).
40. Na Zhang, Yang Yuanxin & Xu Daichao. Emerging roles of palmitoylation in pyroptosis. Trends in cell biology 35, 500-514 (2025).
41. Siya Zhang, Wang Hong-Yin, Tao Xuan, Chen Zhongwen, Levental Ilya & Lin Xubo. Palmitoylation of PD-L1 Regulates Its Membrane Orientation and Immune Evasion. Langmuir 41, 5170-5178 (2025).
42. Shiping Zhang, Wang Linfang, Yi Shuanglong, Tsai Yu-Ting, Cheng Yi-Hsuan, Lin Yu-Tung, Lin Chia-Ching, Lee Yi-Hua, Wang Honglei, Li Shuhua, Wang Ruiqi, Liu Yang, Yan Wei, Liu Chang, He Kai-Wen & Ho Margaret S. Drosophila aux orchestrates the phosphorylation-dependent assembly of the lysosomal V-ATPase in glia and contributes to SNCA/α-synuclein degradation. Autophagy 21, 1039-1058 (2025).
43. Qinyue Zhao, Tao Youqi, Yao Yuxuan, Liu Kaien, Lv Shiran, Cui Bingyao, Xiao Weidi, Cao Tianyi, Li Weidong, Gao Feng, Shen Yong, Wang Chu, Ma Chao, Qiu Wenying, Liu Cong & Li Dan. Unraveling Alzheimer's complexity with a distinct Aβ42 fibril type and specific AV-45 binding. Nature Chemical Biology (2025).
44. Yusai Zhao, Chen Xiaoqing, Zhang Hengwei, Ge Yifan & Li Di. Reversal Drug Resistance of Tumor Cells by Manipulating its Membrane Heterogeneity through High Spatially Resolved Heating. ACS applied bio materials 8, 5291-5300 (2025).
45. Xindi Zhou, Zhang Huijing, Wang Yaru, Wang Danni, Lin Zhiqiao, Zhang Yuchao, Tang Yubin, Liu Jianping, Yao Yu-Feng, Zhang Yixiao & Pan Lifeng. Shigella effector IpaH1.4 subverts host E3 ligase RNF213 to evade antibacterial immunity. Nature Communications 16 (2025).
46. Bowen Zhu, Li Dean, Han Guojing, Yao Xue, Gu Hongqin, Liu Tao, Liu Linghua, Dai Jie, Liu Isabella Zhaotong, Liang Yanlin, Zheng Jian, Sun Zheming, Lin He, Liu Nan, Yu Haidong, Shi Meifang, Shen Gaofang, Hu Zhaohui & Qu Lefeng. Multiplexing and massive parallel sequencing of targeted DNA methylation to predict chronological age. Frontiers in aging 6, 1467639-1467639 (2025).
47. Yixiao Zhuang, Zhang Xinyi, Zhang Shuang, Sun Yunpeng, Wang Hui, Chen Yuxuan, Zhang Hanyin, Zou Penglai, Feng Yonghao, Lu Xiaodan, Chen Peijie, Xu Yi, Li John Zhong, Gao Huanqing, Jin Li & Kong Xingxing. Chaperone-mediated autophagy manipulates PGC1α stability and governs energy metabolism under thermal stress. Nature Communications 16 (2025).
